CLINICAL-EXPERIENCE WITH INTRA LYMPHATIC ADMINISTRATION OF IN-111 LABELED MONOCLONAL-ANTIBODY PAY-276 FOR THE DETECTION OF PELVIC NODAL METASTASES IN PROSTATIC-CARCINOMA
CLINICAL-EXPERIENCE WITH INTRA LYMPHATIC ADMINISTRATION OF IN-111 LABELED MONOCLONAL-ANTIBODY PAY-276 FOR THE DETECTION OF PELVIC NODAL METASTASES IN PROSTATIC-CARCINOMA
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DOI：
10.1007/bf01146853
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发表时间：
1990-03-01
期刊：
影响因子：
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通讯作者：
HALVERSON, C
中科院分区：
文献类型：
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作者：
ABDELNABI, HH;ORTMANNABI, JA;HALVERSON, C
本文报告5例前列腺癌患者双足淋巴管内注射~（111）In-PAY 276（抗前列腺酸性磷酸酶抗体）后，对盆腔淋巴结转移的诊断能力。将标记的抗体直接注射到每只脚的踝关节。在分期盆腔淋巴结切除术中切除的淋巴结的平面和断层图像放射性含量与组织学和免疫过氧化物酶结果进行了比较。盆腔淋巴结中的放射性在注射后20分钟内明显可见，并在16天后存在。在注射后16天，在所有患者中也观察到示踪剂在下肢神经中的持续积聚。无肿瘤淋巴结的放射性计数高于切除的肿瘤淋巴结。我们的研究结果表明，111 In标记的PAY 276单克隆抗体的淋巴内给药具有主要的技术局限性，需要进一步研究示踪剂在淋巴结和无肿瘤淋巴结中积聚的原因。
The ability of 111In-PAY 276 (anti prostatic acid phosphatase antibody) in detecting pelvic lymph node metastasis following bipedal intra lymphatic administration was studied in five patients with carcinoma of the prostate. The labeled antibody was injected directly ito the lymphatics of each foot. Planar and tomographic images radioactivity content of lymph nodes resected during staging pelvic lymphadenectomy were compared to the histologic and immunoperoxidase findings. Radioactivity in pelvic lymph nodes was prominently seen within 20 min of injection and was present 16 days later. Persistent accumulation of tracer in the lymphatics of the lower extremities was also observed in all patients 16 days post injection. Radioactivity counts in tumor-free lymph nodes were higher than in tumored lymph nodes resected. Our results demonstrate that intra lymphatic administration of 111In-labeled PAY 276 monoclonal antibody has major technical limitations, and that further research directed at the causes of tracer accumulation in the lymphatics and tumor-free lymph nodes is required.