Antitumor Activities and Immunomodulatory Effects of Ginseng Neutral Polysaccharides in Combination with 5-Fluorouracil
Antitumor Activities and Immunomodulatory Effects of Ginseng Neutral Polysaccharides in Combination with 5-Fluorouracil
复制标题
人参中性多糖联合5-氟尿嘧啶的抗肿瘤活性和免疫调节作用
DOI：
10.1089/jmf.2009.1119
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发表时间：
2010-04-01
影响因子：
2.4
通讯作者：
Tai, Guihua
中科院分区：
文献类型：
--
作者：
Ni, Weihua;Zhang, Xu;Tai, Guihua
采用热水提取和deae -纤维素层析法制备的人参中性多糖（WGPN）单独及与5-氟尿嘧啶（5-FU）联合灌胃对Sarcoma-180 （S180）荷瘤小鼠的抗癌活性进行了研究。WGPN单用抑制S180肿瘤生长呈钟形剂量-反应曲线，与5-FU联用具有协同作用。对携带s180小鼠的各种免疫活性研究表明，WGPN刺激淋巴细胞增殖，增加自然杀伤细胞的细胞毒性，增强巨噬细胞的吞噬和一氧化氮的产生，提高血清中肿瘤坏死因子-a的水平。WGPN与5-FU联合可减轻5-FU对s180小鼠免疫系统的损伤。这些结果提示WGPN可能是化疗药物的潜在辅助药物。
A neutral polysaccharide fraction (WGPN) prepared from Panax ginseng C. A. Meyer by hot water extraction and DEAE-cellulose chromatography was tested for its anticancer activity alone and in combination with 5-fluorouracil (5-FU) in Sarcoma-180 (S180) tumor-bearing mice by intragastric administration. WGPN alone inhibited S180 tumor growth in a bell-shaped dose-response curve, and the combination with 5-FU showed a synergistic effect. Studies of various immunological activities in S180-bearing mice revealed that WGPN stimulated the proliferation of lymphocytes, increased natural killer cell cytotoxicity, enhanced the phagocytosis and nitric oxide production by macrophages, and increased the level of tumor necrosis factor-a in serum. In combination with 5-FU, WGPN mitigated damage to the immune system caused by 5-FU in S180-bearing mice. These results suggest that WGPN might be a potential adjuvant for chemotherapeutic drugs.