Amino acids-incorporated nanoflowers with an intrinsic peroxidase-like activity.
Amino acids-incorporated nanoflowers with an intrinsic peroxidase-like activity.
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DOI：
10.1038/srep22412
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发表时间：
2016-03-01
影响因子：
4.6
通讯作者：
Li ZQ
中科院分区：
文献类型：
--
作者：
Wu ZF;Wang Z;Zhang Y;Ma YL;He CY;Li H;Chen L;Huo QS;Wang L;Li ZQ
近年来，通过无机盐和氨基酸自组装合成的功能分子引起了广泛关注。本文报道了一种使用铜（II）离子作为无机成分、天然氨基酸作为有机成分来制造杂化有机-无机纳米花的简单方法。结果表明，氨基酸和铜离子之间的相互作用导致了由C、N、Cu、P和O元素组成的纳米花的生长。纳米花中存在Cu离子和含有Cu-O键的Cu(AA)n络合物。纳米花具有以氨基酸R基团为主的花状多孔结构，具有高比表面积，有利于以ABTS和罗丹明B为底物依靠类芬顿反应机制发挥其过氧化物酶样活性。预计纳米花作为酶模拟物在生物传感器、生物分析和生物催化领域的应用具有广阔的前景。
Functional molecules synthesized by self-assembly between inorganic salts and amino acids have attracted much attention in recent years. A simple method is reported here for fabricating hybrid organic–inorganic nanoflowers using copper (II) ions as the inorganic component and natural amino acids as the organic component. The results indicate that the interactions between amino acid and copper ions cause the growth of the nanoflowers composed by C, N, Cu, P and O elements. The Cu ions and Cu(AA)n complexes containing Cu-O bond are present in the nanoflowers. The nanoflowers have flower-like porous structure dominated by the R groups of amino acids with high surface-to-volume ratios, which is beneficial for exerting its peroxidase-like activity depending on Fenton-like reaction mechanism with ABTS and Rhodamine B as the substrates. It is expected that the nanoflowers hold great promise as enzyme mimics for application in the field of biosensor, bioanalysis and biocatalysis.