Chronic stress sensitizes frontal cortex dopamine release in response to a subsequent novel stressor: Reversal by naloxone
Chronic stress sensitizes frontal cortex dopamine release in response to a subsequent novel stressor: Reversal by naloxone
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DOI：
10.1016/s0361-9230(98)00179-8
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发表时间：
1999-02-01
影响因子：
3.8
通讯作者：
Molina, V
中科院分区：
文献类型：
--
作者：
Caudra, G;Zurita, A;Molina, V
本研究考察了早期慢性可变应激过程同时或不同时给予不同剂量纳洛酮（1、2或3 mg/kg， i.p）对体内应激（抑制）诱导的额叶皮层多巴胺释放的影响。与没有慢性应激暴露的大鼠相比，慢性应激大鼠对随后的约束事件的反应中皮质多巴胺释放增加更高。纳洛酮预处理仅在较高剂量（3mg /kg, i.p.）时使这种致敏反应正常化。目前的研究结果表明，皮质多巴胺对一种新的、不可控的应激源的反应在暴露于慢性可变应激过程后致敏，而内源性阿片机制可能在慢性应激过程中被激活，可能参与了这种致敏过程的发展。(C) 1999 Elsevier Science Inc.；
The present study examined the influence of an early chronic variable stress procedure with or without concurrent naloxone administration at different doses (1, 2 or 3 mg/kg, i.p,) on stress (restraint)-induced dopamine release in the frontal cortex in vivo. A higher increase in cortical dopamine release in response to a subsequent restraint event was observed in chronically stressed rats as compared with those without chronic stress exposure. Naloxone pretreatment normalized this sensitized response only at the higher dose (3 mg/kg, i.p.). The present results indicate that cortical dopamine response to a novel and uncontrollable stressor sensitizes after exposure to a chronic variable stress procedure and that an endogenous opiate mechanism, presumably activated during chronic stress, may be involved in the development of such a sensitization process. (C) 1999 Elsevier Science Inc.