IFN-γ, IL-17 and TGF-β involvement in shaping the tumor microenvironment: The significance of modulating such cytokines in treating malignant solid tumors.
IFN-γ, IL-17 and TGF-β involvement in shaping the tumor microenvironment: The significance of modulating such cytokines in treating malignant solid tumors.
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DOI：
10.1186/1475-2867-11-33
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发表时间：
2011-09-23
影响因子：
5.8
通讯作者：
Matalka KZ
中科院分区：
文献类型：
--
作者：
Alshaker HA;Matalka KZ
多种先天性和适应性免疫效应细胞和分子参与癌细胞的识别和破坏，以防止肿瘤生长，这一概念被称为癌症免疫监视。不幸的是，癌细胞能够通过免疫选择免疫原性差的肿瘤细胞变体沿着免疫系统的破坏来避免这一过程，从而形成肿瘤及其微环境。细胞因子是复杂的免疫应答模式的一部分，可以帮助癌症的发展，也可以消除癌症。同时，大量的细胞因子可能参与宿主和肿瘤细胞之间复杂的相互作用，在这种相互作用中，肿瘤和免疫系统之间的动态串扰可以调节肿瘤的生长，或者发生肿瘤的生长、侵袭和转移。在这篇综述中，我们强调浸润的免疫细胞和肿瘤细胞之间的界面，重点是特定细胞因子的双向活动：IFN-γ、TGF-β和IL-17在肿瘤微环境中的作用及其在塑造肿瘤微环境中的作用。此外，调节这些细胞因子有利于抗-肿瘤反应的讨论和优点的靶向调节剂的混合物的使用，以克服在肿瘤微环境中的细胞因子的网络复杂性。
Multiple innate and adaptive immune effector cells and molecules partake in the recognition and destruction of cancer cells to protect against growing tumors, a concept that is known as cancer immunosurveillance. Unfortunately, cancer cells are capable of avoiding this process by immunoselection of poorly immunogenic tumor cells variants along with subversion of the immune system and thus shaping both the tumor and its microenvironment. Cytokines represent part of the complex pattern of the immune response which can assist the development of cancer as well as to eliminate it. Simultaneously, a large number of cytokines may be involved in the complex interactions between host and tumor cells where this dynamic cross-talk, between tumors and the immune system, can either regulate tumor growth or tumor growth, invasion and metastasis take place. In this review, we are stressing on the interface between infiltrated immune cells and tumor cells with the emphasis on the bidirectional activities of specific cytokines: IFN-γ, TGF-β and IL-17 within the tumor microenvironment and their role in shaping it. In addition, the significance of modulating such cytokines in favor of anti-tumor response is discussed and merits the use of mixture of targeted modulators to overcome the network complexity of cytokines in the tumor microenvironment.
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影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
影响因子：
5.8
作者：
Agarwal, A;Verma, S;Saxena, S
通讯作者：
Saxena, S
DOI：
10.1073/pnas.0408197102
发表时间：
2005-01-11
影响因子：
11.1
作者：
Chen, ML;Pittet, MJ;Khazaie, K
通讯作者：
Khazaie, K
影响因子：
15.9
作者：
Charles, Kellie A.;Kulbe, Hagen;Hagemann, Thorsten
通讯作者：
Hagemann, Thorsten
影响因子：
4.4
作者：
Dunn, GP;Ikeda, H;Schreiber, RD
通讯作者：
Schreiber, RD