Predictors of BRCA1/2 genetic testing among Black women with breast cancer: a population-based study
Predictors of BRCA1/2 genetic testing among Black women with breast cancer: a population-based study
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DOI：
10.1002/cam4.1120
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发表时间：
2017-07-01
期刊：
影响因子：
4
通讯作者：
Armstrong, Katrina
中科院分区：
文献类型：
--
作者：
Jones, Tarsha;McCarthy, Anne Marie;Armstrong, Katrina
有证据表明，与白色女性相比，被诊断患有乳腺癌的黑人女性接受BRCA检测和其他多组基因检测的可能性大大降低，尽管早发性乳腺癌和三阴性乳腺癌（TNBC）的发病率较高。我们的研究确定了在接受乳腺癌治疗的黑人妇女中进行BRCA检测的预测因素，并研究了BRCA检测者和非检测者之间的差异。我们对2007年至2009年期间在宾夕法尼亚州和佛罗里达诊断为局部或区域阶段浸润性乳腺癌的945名18-64岁黑人女性进行了分析。Logistic回归用于确定BRCA 1/2检测的预测因素。少数（27%）（n=252）参与者报告进行了BRCA检测。在多因素分析中，我们发现BRCA检测的感知益处（易感因素）（[OR]，1.16; 95%CI：1.11-1.21; P
Evidence shows that Black women diagnosed with breast cancer are substantially less likely to undergo BRCA testing and other multipanel genetic testing compared to White women, despite having a higher incidence of early-age onset breast cancer and triple-negative breast cancer (TNBC). Our study identifies predictors of BRCA testing among Black women treated for breast cancer and examines differences between BRCA testers and nontesters. We conducted an analysis of 945 Black women ages 18-64 diagnosed with localized or regional-stage invasive breast cancer in Pennsylvania and Florida between 2007 and 2009. Logistic regression was used to identify predictors of BRCA 1/2 testing. Few (27%) (n=252) of the participants reported having BRCA testing. In the multivariate analysis, we found that perceived benefits of BRCA testing (predisposing factor) ([OR], 1.16; 95% CI: 1.11-1.21; P