Exogenous nitric oxide can trigger a preconditioned state through a free radical mechanism, but endogenous nitric oxide is not a trigger of classical ischemic preconditioning
Exogenous nitric oxide can trigger a preconditioned state through a free radical mechanism, but endogenous nitric oxide is not a trigger of classical ischemic preconditioning
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DOI：
10.1006/jmcc.2000.1152
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发表时间：
2000-07-01
影响因子：
5
通讯作者：
Cohen, MV
中科院分区：
文献类型：
--
作者：
Nakano, A;Liu, GS;Cohen, MV
一氧化氮合酶(NO)在兔心脏缺血预适应(PC)的晚期发挥着重要的作用，但其在早期缺血预适应(经典PC)中的作用尚存争议。因此，本研究旨在确定一氧化氮是否参与了经典PC的心脏保护作用。离体心经历30分钟的区域缺血和120分钟的再灌流。用氯化三苯基四氮唑盐测定心肌梗死面积。对照组心梗发生率为30.2+/-3.3%。全脑缺血5min再灌流10min，心肌梗死面积缩小至10.2+/-2.4%(P
Nitric oxide (NO) has been reported to play an important rt,le in the late phase of ischemic preconditioning (PC) in the rabbit heart, However, the role of NO in the early phase of ischemic PC ("classical PC") is controversial. Accordingly, the present study was designed to determine whether NO contributes to the cardioprotective effect of classical PC in rabbits. Isolated hearts experienced 30 min of regional ischemia followed by 120 min of reperfusion. Infarct size was measured with triphenyltetrazolium chloride. In control hearts infarction was 30.2 +/- 3.3 % of the risk zone. PC with 5 min of global ischemia and 10 min of reperfusion reduced infarct size to 10.2 +/- 2.4% (P