A super-resolution ultrasound method for brain vascular mapping
A super-resolution ultrasound method for brain vascular mapping
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DOI：
10.1118/1.4823762
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发表时间：
2013-11-01
期刊：
影响因子：
3.8
通讯作者：
Hynynen, Kullervo
中科院分区：
文献类型：
--
作者：
O'Reilly, Meaghan A.;Hynynen, Kullervo
目的：由于当前临床成像方式的限制，尚未在大脑中实现高分辨率血管成像。作者提出了一种对管体模型内单个微米大小的气泡进行经颅超声成像的方法。方法：使用稀疏半球形接收器阵列和无源波束形成算法，通过离体人类头骨映射管体模型内单个气泡的发射。应用无创相位和幅度校正技术来补偿颅骨的畸变效应。对单个气泡的位置进行估计，超出超声的衍射极限，以产生管体模型的超分辨率图像，并将其与微型计算机断层扫描 (micro-CT) 进行比较。结果：所得的超分辨率超声图像与通过微型 CT 进行小组织样本成像获得的结果相当。结论：该方法提供了比深部组织对比超声更高的分辨率，并且有可能扩展到提供大脑中完整的血管网络成像。 (C) 2013 年美国医学物理学家协会。
Purpose: High-resolution vascular imaging has not been achieved in the brain due to limitations of current clinical imaging modalities. The authors present a method for transcranial ultrasound imaging of single micrometer-size bubbles within a tube phantom.Methods: Emissions from single bubbles within a tube phantom were mapped through an ex vivo human skull using a sparse hemispherical receiver array and a passive beamforming algorithm. Noninvasive phase and amplitude correction techniques were applied to compensate for the aberrating effects of the skull bone. The positions of the individual bubbles were estimated beyond the diffraction limit of ultrasound to produce a super-resolution image of the tube phantom, which was compared with microcomputed tomography (micro-CT).Results: The resulting super-resolution ultrasound image is comparable to results obtained via the micro-CT for small tissue specimen imaging.Conclusions: This method provides superior resolution to deep-tissue contrast ultrasound and has the potential to be extended to provide complete vascular network imaging in the brain. (C) 2013 American Association of Physicists in Medicine.