The vomeronasal chemosensory system as a route of neuroinvasion by herpes simplex virus
The vomeronasal chemosensory system as a route of neuroinvasion by herpes simplex virus
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DOI：
10.1016/j.virol.2005.01.023
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发表时间：
2005-03-30
期刊：
影响因子：
3.7
通讯作者：
Nishiyama, Y
中科院分区：
文献类型：
--
作者：
Mori, I;Goshima, F;Nishiyama, Y
我们研究了嗜神经性微生物通过周围神经系统入侵中枢神经系统(CNS)的可能性。单纯疱疹病毒1型(HSV-1)Kh6株和单纯疱疹病毒2型(HSV-2)186株经鼻接种小鼠后，可感染犁鼻器(信息素检测器)的化学感受神经元。HSV-1株Kh6感染进一步传播到副嗅球(第一次接力)、杏仁内侧核(第二次接力)、终纹床核和下丘脑腹内侧(第三次接力)。HSV-1株Kh6也针对嗅觉和三叉神经系统。单纯疱疹病毒2型186株主要攻击脑干，包括三叉神经系统。虽然这两种病毒都不会诱导受感染的化学感觉神经元的凋亡，但它们会在受感染的脑组织中诱导细胞凋亡。这些结果表明，嗜神经性病毒可以通过感染犁鼻化学感受器神经元来入侵大脑，感染神经元中诱导的凋亡受到抑制可能有助于病毒向中枢神经系统的传播。(C)2005 Elsevier Inc.保留所有权利。
We have investigated the potential of neurotropic microbes to invade the central nervous system (CNS) via the peripheral nervous system. Herpes simplex virus type 1 (HSV-1) strain KH6 and herpes simplex virus type 2 (HSV-2) strain 186 were found to infect chemosensory neurons in the vomeronasal organ (the pheromone detector) following intranasal inoculation of mice. HSV-1 strain KH6 infection was further transmitted to the accessory olfactory bulb (first relay), the medial amygdala (second relay), and the bed nucleus of the stria terminalis and the ventromedial hypothalamus (third relay). HSV-1 strain KH6 also targeted the olfactory and trigeminal systems. HSV-2 strain 186 predominantly attacked the brainstem including the trigeminal system. While both viruses did not induce apoptosis in infected chemosensory neurons, they did in infected brain tissue. These results suggest that neurotropic viruses can invade the brain by infecting vomeronasal chemosensory neurons and that the restrained induction of apoptosis in the infected neurons may facilitate viral transmission to the CNS. (c) 2005 Elsevier Inc. All rights reserved.