Peripheral T cell lymphoma, not otherwise specified with myelofibrosis: report of a case with review of the literature.
Peripheral T cell lymphoma, not otherwise specified with myelofibrosis: report of a case with review of the literature.
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外周 T 细胞淋巴瘤，未另外指定为骨髓纤维化：病例报告及文献综述。
DOI：
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发表时间：
2015
影响因子：
1.4
通讯作者：
M. Noguchi
中科院分区：
文献类型：
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作者：
Y. Sekiguchi;Syuichi Shirane;Asami Shimada;Kunimoto Ichikawa;M. Wakabayashi;K. Sugimoto;S. Tomita;H. Izumi;N. Nakamura;T. Sawada;Y. Ohta;N. Komatsu;M. Noguchi
一位68岁的男性患者因全血细胞减少症、红皮病和多发性淋巴结病就诊。淋巴结活检诊断为外周T细胞淋巴瘤-未另行说明（PTCL-NOS）。淋巴结活检标本的细胞因子免疫染色显示，肿瘤细胞对平板衍生生长因子（PDGF）、碱性成纤维细胞生长因子（b-FGF）、血管内皮生长因子（VEGF）、肿瘤坏死因子α（TNF-α）、干扰素-γ（IFN-γ）、白细胞介素-1 β（IL-1β）、白细胞介素-2（IL-2）和转化生长因子-β（TGF-β）呈阳性。骨髓活检显示PTCL-NOS和骨髓纤维化（MF）浸润。骨髓血对JAK-2 V617 F呈阴性。骨髓细胞因子免疫组化染色显示肿瘤细胞呈PDGF、b-FGF、VEGF、TNF-α、IFN-γ、IL-1β、IL-2和TGF-β阳性。患者开始接受治疗，在CHOP治疗的第一个疗程后，PTCL-NOS和MF的骨髓浸润改善。骨髓活检标本细胞因子免疫组化染色显示肿瘤细胞PDGF、VEGF、TNF-α和TGF-β均为阴性。然而，在第二疗程CHOP治疗后，PTCL-NOS和MF的骨髓浸润恶化。骨髓标本细胞因子免疫染色再次显示肿瘤细胞PDGF、TNF-α和TGF-β阳性染色结果。在第一个疗程结束时，PTCL-NOS的浸润改善，但全血细胞减少症没有改善。
A 68-year-old man presented to us with pancytopenia, erythroderma, and multiple lymphadenopathies. Lymph node biopsy led to the diagnosis of peripheral T-Cell lymphoma-not otherwise specified (PTCL-NOS). Immunostaining of the lymph node biopsy specimens for cytokines revealed that the tumor cells were positive for plated-derived growth factor (PDGF), basic fibroblast growth factor (b-FGF), vascular endothelial growth factor (VEGF), tumor necrosis factor α (TNF-α), interferon-γ (IFN-γ), interleukin-1β (IL-1β), interleukin-2 (IL-2), and transforming growth factor-β (TGF-β). Bone marrow biopsy revealed infiltration by the PTCL-NOS and myelofibrosis (MF). Bone marrow blood was negative for JAK-2V617F. Bone marrow immunostaining for cytokines showed that the tumor cells were positive for PDGF, b-FGF, VEGF, TNF-α, IFN-γ, IL-1β, IL-2, and TGF-β. The patient was initiated on treatment, and after the first course of CHOP therapy, the bone marrow infiltration by the PTCL-NOS and MF improved. Repeat immunostaining of bone marrow biopsy specimens for cytokines showed that the tumor cells had become negative for PDGF, VEGF, TNF-α and TGF-β. However, after the second course of CHOP therapy, the bone marrow infiltration by the PTCL-NOS and MF worsened. Immunostaining of bone marrow specimens for cytokines again revealed positive staining results of the tumor cells for PDGF, TNF-α, and TGF-β. At the completion of the first course of treatment, the infiltration by the PTCL-NOS improved, but not the pancytopenia.
外周 T 细胞淋巴瘤与骨髓纤维化伴血浆转化生长因子-β1 升高。
DOI：
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发表时间：
2005
期刊：
Leuk Lymphoma. 46 4
影响因子：
--
作者：
Ito K;Nakazato T;et al.;Takedatsu.H;Hashiguchi M;Takedatsu. H;Mori. T;Takedatsu. H;Ohtsubo K;Okabe s et al.;Tauchi t et al.;Okabe s et al.
通讯作者：
Okabe s et al.