Transmission of pruriceptive signals.
Transmission of pruriceptive signals.
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DOI：
10.1007/978-3-662-44605-8_8
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发表时间：
2015
影响因子：
--
通讯作者：
Hoon MA
中科院分区：
文献类型：
--
作者：
Mishra SK;Hoon MA
在本章中，我们讨论了许多关于瘙痒传播机制的最新发现：神经递质及其引发的反应，特定神经元靶点被激活的机制，以及通路的特异性。目前的数据显示，DRG神经元和脊髓细胞使用一组非常有选择性的递质将瘙痒信息从外周传递到大脑：谷氨酸和Nppb从初级瘙痒感觉细胞释放;这些分子激活次级脊髓疼痛感受特异性神经元，后者又利用Grp激活三级疼痛感受选择性神经元。强啡肽和表达生长抑素受体的神经元的抑制性输入与这种基本的线性兴奋性通路相交，从而改变瘙痒感觉。累积起来，这些研究描绘了一幅关于瘙痒信号如何在脊髓中转化和整合的优雅而简单的画面，并为旨在理解和更好地治疗瘙痒的研究工作开辟了新的途径。
In this chapter we discuss the many recent discoveries of the mechanisms by which itch is transmitted: the neurotransmitters and the responses they trigger, the mechanisms by which specific neuronal targets are activated, and the specificity of the pathways. Current data reveal that DRG-neurons and spinal cord cells use a remarkably selective set of transmitters to convey pruritic information from the periphery to the brain: glutamate and Nppb are released from primary itch-sensory cells; these molecules activate secondary spinal cord pruriceptive specific neurons, which in turn utilize Grp to activate tertiary pruriceptive selective neurons. Intersecting this basic linear excitatory pathway, inhibitory input from dynorphin and neurons that express the somatostatin receptor modify itch-sensation. Cumulatively, these studies paint an elegantly simple picture of how itch signals are transformed and integrated in the spinal cord, and open new avenues for research efforts aimed at understanding and better treating itch.