Dietary Linoleic Acid and Glucose Enhances Azoxymethane-Induced Colon Cancer and Metastases via the Expression of High-Mobility Group Box 1
Dietary Linoleic Acid and Glucose Enhances Azoxymethane-Induced Colon Cancer and Metastases via the Expression of High-Mobility Group Box 1
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DOI：
10.1159/000296305
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发表时间：
2010-01-01
期刊：
影响因子：
5
通讯作者：
Kuniyasu, Hiroki
中科院分区：
文献类型：
--
作者：
Ohmori, Hitoshi;Luo, Yi;Kuniyasu, Hiroki
目的：高迁移率族蛋白B1（HMGB1）与结直肠癌的进展和转移密切相关。研究方法：我们研究了HMGB1在由氧化偶氮甲烷（AOM）注射诱导的Fischer 344大鼠结肠癌发生中的意义，所述Fischer 344大鼠喂养对照饮食（C组）、15%亚油酸（LA）饮食（L组）、对照饮食+10%葡萄糖饮料（G组）和15% LA饮食+10%葡萄糖饮料（L+G组）。结果：L+G组体重和热量摄入最高。血清和粘膜HMGB1水平在所有组中均暂时升高，而L+G组中观察到最高水平。粘液HMGB1水平与癌症多样性和淋巴结转移相关。在AOM注射大鼠喂食15%LA饮食和10%葡萄糖饮料，HMGB1抗体的管理抑制血清HMGB1浓度和癌症的多样性。结论：LA和葡萄糖对AOM诱导的大鼠结肠癌具有协同作用，其机制可能与诱导HMGB1的表达有关。版权所有（C）2010 S. Karger AG，巴塞尔
Objective: High-mobility group box 1 (HMGB1) was closely associated with progression and metastasis of colorectal cancer. Methods: We examined the significance of HMGB1 in causing colon carcinogenesis induced by azoxymethane (AOM) injection in Fischer 344 rats fed on a control diet (group C), a 15% linoleic acid (LA) diet (group L), a control diet with 10% glucose drink (group G), and a 15% LA diet with a 10% glucose drink (group L+G). Results: Group L+G showed the highest body weight and calorie intake. Serum and mucosal HMGB1 levels were temporally increased in all groups, while the highest levels were observed in group L+G. Mucosal HMGB1 levels were correlated with cancer multiplicity and nodal metastases. In the AOM-injected rats fed the 15% LA diet with 10% glucose drink, administration of HMGB1 antibody suppressed serum HMGB1 concentration and cancer multiplicity. Conclusion: These data suggest that dietary LA and glucose provided the synergistic effect on AOM-induced rat colon cancer through HMGB1 induction. Copyright (C) 2010 S. Karger AG, Basel