FDG-PET as an independent biomarker for Alzheimer's biological diagnosis: a longitudinal study
FDG-PET as an independent biomarker for Alzheimer's biological diagnosis: a longitudinal study
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FDG-PET 作为阿尔茨海默病生物诊断的独立生物标志物：一项纵向研究。
DOI：
10.1186/s13195-019-0512-1
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发表时间：
2019-06-29
影响因子：
9
通讯作者：
Yu, Jin-Tai
中科院分区：
文献类型：
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作者：
Ou, Ya-Nan;Xu, Wei;Yu, Jin-Tai
在最近提出的阿尔茨海默病（AD）生物学定义的ATN框架中，减少的f -18氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）脑代谢被认为是神经退行性变的生物标志物。然而，越来越多的证据表明它是一个独立的生物标志物，在本研究中用F表示。方法从阿尔茨海默病神经影像学倡议数据库中招募551例A+T+患者，根据生物标志物阳性程度将其分为4组，分别为132例A+T+N-F-、102例A+T+N-F+、113例A+T+N+F-和204例A+T+N+F+。比较各组的频率分布，以及每对F+组和F-组之间的临床进展[通过认知和脑结构的纵向变化以及轻度认知障碍（MCI）到AD痴呆的转化来衡量]。结果A+T+N+F+型在临床诊断为AD痴呆患者中的患病率为66.24%；同样，大多数FDG-PET降低的个体是AD痴呆受试者。在纳入的551人中，537人至少进行了一次随访（随访时间从1年到8年不等）。与F-组相比，F+组个体在简易精神状态检查量表中的表现更差，下降更快，中颞叶萎缩更快（p < 0.05）
BackgroundReduced F-18-fluorodeoxyglucose-positron emission tomography (FDG-PET) brain metabolism was recognized as a biomarker of neurodegeneration in the recently proposed ATN framework for Alzheimer's disease (AD) biological definition. However, accumulating evidence suggested it is an independent biomarker, which is denoted as F in the very study.MethodsA total of 551 A+T+ individuals from the Alzheimer's Disease Neuroimaging Initiative database were recruited and then further divided into four groups based on the biomarker positivity as 132 A+T+N-F-, 102 A+T+N-F+, 113 A+T+N+F-, and 204 A+T+N+F+. Frequency distributions of the groups were compared, as well as the clinical progression [measured by the longitudinal changes in cognition and brain structure, and mild cognitive impairment (MCI) to AD dementia conversion] between every pair of F+ and F- groups.ResultsThe prevalence of A+T+N+F+ profile was 66.24% in clinically diagnosed AD dementia patients; similarly, the majority of individuals with reduced FDG-PET were AD dementia subjects. Among the 551 individuals that included, 537 had at least one follow-up (varied from 1 to 8years). Individuals in F+ groups performed worse and dropped faster in Mini-Mental State Examination scale and had faster shrinking middle temporal lobe than those in F- groups (all p