Mechanisms of DNA Repair by Photolyase and Excision Nuclease (Nobel Lecture)
Mechanisms of DNA Repair by Photolyase and Excision Nuclease (Nobel Lecture)
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DOI：
10.1002/anie.201601524
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发表时间：
2016-07-18
影响因子：
16.6
通讯作者：
Sancar, Aziz
中科院分区：
文献类型：
--
作者：
Sancar, Aziz
本文介绍了一项研究的结果，该研究检查了大肠杆菌中通过光裂合酶进行的 DNA 修复以及微生物和人类中的核苷酸切除修复。考虑的变量包括 (UVrA)2 同二聚体在识别 DNA 损伤位点中的作用、大肠杆菌转录偶联修复的机制以及人类切除 DNA 修复。讨论了单核苷酸分辨率下人类基因组的切除修复图。
The article presents the result of a study which examined DNA repair through photolyase in Escherichia coli and nucleotide excision repair in both microorganism and humans. The variables considered include the role of the (UVrA)2homodimer in identifying the DNA damage site, the mechanism of Escherichia coli transcription-coupled repair, and excision DNA repair in humans. A discussion on the excision repair map of the human genome at single nucleotide resolution is offered.