Audio-visual experience strengthens multisensory assemblies in adult mouse visual cortex
Audio-visual experience strengthens multisensory assemblies in adult mouse visual cortex
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DOI：
10.1038/s41467-019-13607-2
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发表时间：
2019-12-12
影响因子：
16.6
通讯作者：
Barnes, Samuel J.
中科院分区：
文献类型：
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作者：
Knopfel, Thomas;Sweeney, Yann;Barnes, Samuel J.
我们同时通过多种感官体验世界。为了更好地理解多感觉加工的机制，我们询问来自两种感觉(听觉和视觉)的输入是否能够相互作用并驱动初级视觉皮质(V1)神经回路的可塑性。使用遗传编码的电压和钙指示器，我们发现一致的视听体验改变了小鼠V1的L2/3神经元的阈值上和阈值下反应特性。具体地说，我们发现，在视听配对之后，一部分多模式神经元对配对的听觉刺激产生了增强的听觉反应。这种跨模式的可塑性持续数天，反映在L2/3神经元的小功能网络的加强上。我们发现，在感觉驱动的共同活动中，V1通过加强多模式神经元功能特定组件之间的功能关联来处理一致的听觉和视觉事件，在大脑皮层网络中留下了一丝多感觉体验的痕迹。
We experience the world through multiple senses simultaneously. To better understand mechanisms of multisensory processing we ask whether inputs from two senses (auditory and visual) can interact and drive plasticity in neural-circuits of the primary visual cortex (V1). Using genetically-encoded voltage and calcium indicators, we find coincident audio-visual experience modifies both the supra and subthreshold response properties of neurons in L2/3 of mouse V1. Specifically, we find that after audio-visual pairing, a subset of multimodal neurons develops enhanced auditory responses to the paired auditory stimulus. This cross-modal plasticity persists over days and is reflected in the strengthening of small functional networks of L2/3 neurons. We find V1 processes coincident auditory and visual events by strengthening functional associations between feature specific assemblies of multimodal neurons during bouts of sensory driven co-activity, leaving a trace of multisensory experience in the cortical network.