Msx-2 and the regulation of organ size: epidermal thickness and hair length.
Msx-2 and the regulation of organ size: epidermal thickness and hair length.
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Msx-2和器官大小的调节：表皮厚度和毛发长度。
DOI：
10.1038/sj.jidsp.5640229
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Chuong,CM
中科院分区：
文献类型：
--
作者：
Wang,WP;Widelitz,RB;Jiang,TX;Chuong,CM
在器官发生过程中，大小调节与形状和分化一样重要。我们认为，上皮及其附属物尺寸（长度、宽度、厚度）的调节是基于特定部位细胞数量的调节，反映了该区域细胞的输入和输出。这一过程又受到从增殖细胞域到有丝分裂后分化细胞域的流动的调节。当同源异型盒基因Msx-2在CMV启动子控制下在转基因小鼠中过表达时，表皮增厚，过度增殖和过度角化。毛发变短，基质区缩小。我们认为Msx-2可能是参与器官大小控制的调节因子之一，上述表型是组织中从增殖域到分化域的细胞流动增加的表现。
During organogenesis, the issue of size regulation is as important as shape and differentiation. We propose that the regulation of the dimensions of the epithelium and its appendages (length, width, thickness) are based on regulation of cell numbers in specific sites, reflecting the input and output of cells in that region. This process is in turn regulated by the flow from the domain of proliferating cells to the domain of postmitotic differentiated cells. When the homeobox gene Msx-2 is over-expressed in transgenic mice under the control of the CMV promoter, the epidermis is thickened with hyperproliferation and hyperkeratosis. Hairs are shorter and the matrix region is shrunken. We suggest that Msx-2 may be one of the regulators involved in the control of organ size, and the above phenotypes are the manifestations of an increased cellular flow from proliferation domain to differentiation domain in the tissue.