Animal models of glucocorticoid-induced glaucoma.
Animal models of glucocorticoid-induced glaucoma.
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DOI：
10.1016/j.exer.2015.06.002
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发表时间：
2015-12
影响因子：
3.4
通讯作者：
Clark AF
中科院分区：
文献类型：
--
作者：
Overby DR;Clark AF
糖皮质激素（GC）疗法被广泛用于治疗各种炎症性疾病和病症。虽然其抗炎和免疫抑制活性无可比拟，但GC治疗通常与GC诱导的高眼压（OHT）和医源性开角型青光眼的显著眼部副作用相关。除了人类，研究人员已经在至少8种不同的物种中产生了气相色谱诱导的OHT和青光眼。这些模型模拟了人类这种情况的许多特征，并为GC-OHT的发病机制提供了形态学和分子上的见解。此外，气相色谱诱导的青光眼与原发性开角型青光眼（POAG）在临床、形态学和分子上有许多相似之处，这使得气相色谱诱导的OHT和青光眼的动物模型成为研究POAG具体方面的理想模型。
Glucocorticoid (GC) therapy is widely used to treat a variety of inflammatory diseases and conditions. While unmatched in their anti-inflammatory and immunosuppressive activities, GC therapy is often associated with the significant ocular side effect of GC-induced ocular hypertension (OHT) and iatrogenic open-angle glaucoma. Investigators have generated GC-induced OHT and glaucoma in at least 8 different species besides man. These models mimic many features of this condition in man and provide morphologic and molecular insights into the pathogenesis of GC-OHT. In addition, there are many clinical, morphological, and molecular similarities between GC-induced glaucoma and primary open-angle glaucoma (POAG), making animals models of GC-induced OHT and glaucoma attractive models in which to study specific aspects of POAG.