The Platelet-to-Lymphocyte Ratio Versus Neutrophil-to-Lymphocyte Ratio: Which is Better as a Prognostic Factor in Gastric Cancer?
The Platelet-to-Lymphocyte Ratio Versus Neutrophil-to-Lymphocyte Ratio: Which is Better as a Prognostic Factor in Gastric Cancer?
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DOI：
10.1245/s10434-015-4518-z
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发表时间：
2015-12-01
影响因子：
3.7
通讯作者：
Song, Kyo Young
中科院分区：
文献类型：
--
作者：
Kim, Eun Young;Lee, Jin Won;Song, Kyo Young
作为全身炎症反应的指标，嗜中性粒细胞与淋巴细胞比率（NLR）和血小板与淋巴细胞比率（PLR）已被提议用于预测某些癌症的临床结局。本研究的目的是探讨NLR和PLR对胃癌预后的影响。根据受试者工作特征分析确定PLR和NLR的最佳截断值。根据截断值将患者分为高、低PLR和NLR组，比较分析两组患者的临床特征，高NLR和PLR组患者预后不良。NLR是影响总生存期的独立预后因素[HR = 1.403; p = 0.023]，而PLR则不是（p = 0.788），虽然PLR和NLR都能反映预后，但NLR比PLR更能预测总生存期。
As indicators of the systemic inflammatory response, the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been proposed to predict the clinical outcome in some cancers. The purpose of this study was to investigate the impact of NLR and PLR on the prognosis of gastric cancer.From 2000 to 2009, 1986 consecutive patients who underwent curative surgery for gastric cancer were enrolled. The optimal cutoff value of PLR and NLR was determined according to receiver operating characteristic analysis. We categorized the patients into the high or low PLR and NLR group based on the cutoff value, and the clinical features of these two groups were comparatively analyzed.The high NLR and PLR groups were significantly associated with poor prognosis. The NLR was an independent prognostic factor for overall survival [hazard ratio (HR) = 1.403; p = 0.023]; however, the PLR was not (p = 0.788).Although both the PLR and NLR can reflect the prognosis, the NLR is more predictive of overall survival than the PLR.