SEX-DEPENDENT INDUCTION OF HUMAN SUPPRESSOR T-CELLS BY CHORIONIC-GONADOTROPIN
SEX-DEPENDENT INDUCTION OF HUMAN SUPPRESSOR T-CELLS BY CHORIONIC-GONADOTROPIN
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DOI：
10.1016/0165-0378(82)90025-0
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发表时间：
1982-01-01
影响因子：
3.4
通讯作者：
BRUNDIN, J
中科院分区：
文献类型：
--
作者：
FUCHS, T;HAMMARSTROM, L;BRUNDIN, J
生理浓度的人绒毛膜促性腺激素（hCG）诱导人雌性淋巴细胞抑制结核菌素纯蛋白衍生物刺激的B细胞增殖和分化。为了测试hCG诱导的抑制是否是性别依赖性的，使用雌性和雄性外周淋巴细胞进行了平行实验。在男性淋巴细胞中，hCG没有诱导能够抑制纯化蛋白衍生物诱导的B细胞增殖的细胞，而女性淋巴细胞中发现了统计学显著的抑制作用。在月经初潮前、绝经后和2例Turner综合征患者中发现了类似的hCG诱导的抑制作用。这表明Y染色体上的基因发挥调节功能，从而阻止激素诱导抑制性T细胞。
Human chorionic gonadotropin (hCG) in physiological retroplacental concentration induces human female lymphocytes which suppress the proliferation and differentiation of B-cells stimulated by purified protein derivative of tuberculin. To test whether the hCG-induced suppression was sex dependent parallel experiments using female and male peripheral lymphocytes were performed. hCG did not induce cells capable of suppressing purified protein derivative induced B cell proliferation in lymphocytes from males, which was in contrast to lymphocytes from females where a statistically significant suppression was found. A similar hCG-induced suppressive effect was found before menarche, after the menopause and in 2 patients with Turner''s syndrome, suggesting that a gene(s) on the Y chromosome exerts a regulatory function and thus prevents the hormone from inducing suppressor T cells.