Increase in serum bone gamma-carboxyglutamic acid protein with aging in women. Implications for the mechanism of age-related bone loss.
Increase in serum bone gamma-carboxyglutamic acid protein with aging in women. Implications for the mechanism of age-related bone loss.
复制标题
女性血清骨γ-羧基谷氨酸蛋白随着年龄的增长而增加。
DOI：
10.1172/jci110882
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Riggs,BL
中科院分区：
文献类型：
--
作者：
Delmas,PD;Stenner,D;Wahner,HW;Mann,KG;Riggs,BL
由于目前尚不清楚年龄相关的骨丢失是否是由于骨吸收增加、骨形成减少或两者兼而有之，我们测定了174名年龄在30至94岁的妇女的骨钙素（BGP）血清水平，BGP是骨转换的特异性标志物。血清BGP随年龄增长呈线性增加（r = 0.44，P <0.001），从40岁时的4.4 ± 0.4（平均值± SE）增加到10岁时的8.9 ± 0.9 ng/ml。这种增加与腰椎、桡骨中段和桡骨远端骨密度的降低呈负相关（P <0.001）。偏相关分析表明，在肌酐清除率固定后，血清BGP仍与年龄呈正相关（r = 0.31，P <0.001），而与肌酐清除率无相关性（r =-0.04，NS）。尿羟脯氨酸（r = 0.29，P <0.001），骨吸收指数和血清碱性磷酸酶（r = 0.31，P <0.001），骨形成的指标，也随着年龄的增长而增加，这些增加与血清BGP的增加有关（r = 0.39，P <0.001; r = 0.43，P <0.001）。血清免疫反应性甲状旁腺激素浓度（r = 0.39，P <0.001）和尿cAMP排泄量（r = 0.38，P <0.001）增加，表明PTH分泌随年龄增加，这些增加与血清BGP的增加显着相关。一个小组的32名妇女谁被发现有椎骨骨折，髋部骨折，或两者有显着较高的血清BGP值比其余的。这些数据表明，随着年龄的增长，女性的整体骨转换增加，特别是考虑到伴随的骨骼质量下降，不支持年龄相关的骨丢失主要是由于骨形成减少的观点。
Because it is unclear whether age-related bone loss results from increased bone resorption, decreased bone formation or both, we measured the serum level of bone Gla-protein (BGP), a specific marker for bone turnover, in 174 women, ages 30 to 94 yr. Serum BGP increased linearly with aging (r = 0.44, P less than 0.001) from 4.4 +/- 0.4 (mean +/- SE) in the 4th decade to 8.9 +/- 0.9 ng/ml in the 10th decade. This increase correlated inversely (P less than 0.001) with concomitant decreases in bone mineral density at the lumbar spine, midradius, and distal radius. Using partial correlation coefficients, serum BGP still correlated positively with age (r = 0.31, P less than 0.001) after creatinine clearance was fixed but not with creatinine clearance (r = -0.04, NS) when age was fixed. Urinary hydroxyproline (r = 0.29, P less than 0.001), an index of bone resorption, and serum alkaline phosphatase (r = 0.31, P less than 0.001), an index of bone formation, also increased with age and these increases correlated with increases in serum BGP (r = 0.39, P less than 0.001 and r = 0.43, P less than 0.001, respectively). Serum immunoreactive parathyroid hormone concentrations (r = 0.39, P less than 0.001) and urinary cyclic AMP excretion (r = 0.38, P less than 0.001) increased, suggesting that PTH secretion increased with age; these increases correlated significantly with increases in serum BGP. A subgroup of 32 women who were found to have vertebral fractures, hip fractures, or both had significantly higher values for serum BGP than the remainder. These data suggest that overall bone turnover increases in women with aging and, especially considering the concomitant decrease in skeletal mass, do not support the view that age-related bone loss results primarily from decreased bone formation.