Exosomes May Be the Potential New Direction of Research in Osteoarthritis Management.
Exosomes May Be the Potential New Direction of Research in Osteoarthritis Management.
复制标题
外泌体可能是骨关节炎治疗研究的潜在新方向。
DOI：
10.1155/2019/7695768
复制
发表时间：
2019-01-01
影响因子：
--
通讯作者：
Zhang, Zhiping
中科院分区：
文献类型：
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作者：
Ju, Cheng;Liu, Renfeng;Zhang, Zhiping
Osteoarthritis (OA) is a joint degenerative disease, which is prominent in the middle-aged and elderly population, often leading to repeated pain in the joints of patients and seriously affecting the life quality of patients. At present, the treatment of OA mainly depends on the surgery and drug treatment. Nevertheless, these treatments still face many problems, such as surgical safety, complications, and drug side effects. Exosomes can be secreted and released by multiple cell types and have lipid bilayer membranes and contain abundant biological molecules, including proteins, lipids, and nucleic acids. Moreover, exosomes play a critical role in local and distal intercellular and intracellular communication. In recent years, several studies have found that exosomes can regulate the progression of OA and have a potential efficacy for OA treatment. Thus, in this article, we summarize and review the relevant research of exosomes in OA and emphasize the importance of exosomes in the development of OA.
