AHR Function in Lymphocytes: Emerging Concepts.
AHR Function in Lymphocytes: Emerging Concepts.
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DOI：
10.1016/j.it.2015.11.007
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发表时间：
2016-01
影响因子：
16.8
通讯作者：
Zhou L
中科院分区：
文献类型：
--
作者：
Zhou L
芳烃受体（Ahr）是先天性和适应性免疫细胞的发育和功能的重要调节剂，其作用与Ahr对细胞和饮食配体的反应能力相关。最近的研究结果揭示了Ahr在体内平衡和免疫应答过程中的组织和环境特异性功能。我在这里回顾这些发现，并将其整合到目前的理解机制，调节AHR转录和功能。我提出了一个概念框架，其中AHR功能由三个因素决定：在任何给定的细胞中的AHR的量，在某些组织中的AHR配体的丰度和效力，以及AHR+细胞所在的组织微环境。这种复杂性强调了研究Ahr功能的细胞类型特异性遗传方法的必要性。
The aryl hydrocarbon receptor (Ahr) is an important regulator of the development and function of both innate and adaptive immune cells through roles associated with Ahr's ability to respond to cellular and dietary ligands. Recent findings have revealed tissue and context-specific functions for Ahr in both homeostasis and in during an immune response. I review these findings here, and integrate them into the current understanding of the mechanisms that regulate Ahr transcription and function. I propose a conceptual framework in which Ahr function is determined by three factors: the amount of Ahr in any given cell, the abundance and potency of Ahr ligands within certain tissues, and the tissue microenvironment wherein Ahr+ cells reside. This complexity emphasizes the necessity cell-type specific genetic approaches towards the study of Ahr function.