Aberrant Neural Connectivity during Emotional Processing Associated with Posttraumatic Stress.
Aberrant Neural Connectivity during Emotional Processing Associated with Posttraumatic Stress.
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DOI：
10.1177/2167702614530113
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发表时间：
2014-11
期刊：
影响因子：
--
通讯作者：
Heller W
中科院分区：
文献类型：
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作者：
Sadeh N;Spielberg JM;Warren SL;Miller GA;Heller W
考虑到大脑的复杂性，描述分布的大脑区域之间的关系对于描述创伤后应激症状的神经实例可能是至关重要的。本研究采用情绪词Stroop任务，对35名创伤后应激障碍（PTSD）的病理生理学相关的关键脑区之间的功能连接模式进行了研究。PTSD症状的严重程度（特别是过度觉醒症状）缓和杏仁核-mPFC耦合过程中不愉快的话的处理，这种缓和与报告的现实世界的损害和杏仁核的反应性呈正相关。在愉快和不愉快的话中，重新体验严重性会调节校园-校园耦合。结果提供的证据表明，PTSD症状差异温和的功能耦合在情绪干扰，并强调检查网络连接在PTSD研究的重要性。他们认为，过度觉醒与负mPFC-杏仁核耦合有关，而再体验与改变的岛-海马功能有关，连接模式可能代表情感处理过程中功能障碍的抑制控制的可分离指标。
Given the complexity of the brain, characterizing relations among distributed brain regions is likely essential to describing the neural instantiation of posttraumatic stress symptoms. This study examined patterns of functional connectivity among key brain regions implicated in the pathophysiology of posttraumatic stress disorder (PTSD) in 35 trauma-exposed adults using an emotion-word Stroop task. PTSD symptom severity (particularly hyperarousal symptoms) moderated amygdala-mPFC coupling during the processing of unpleasant words, and this moderation correlated positively with reported real-world impairment and amygdala reactivity. Reexperiencing severity moderated hippocampus-insula coupling during pleasant and unpleasant words. Results provide evidence that PTSD symptoms differentially moderate functional coupling during emotional interference and underscore the importance of examining network connectivity in research on PTSD. They suggest that hyperarousal is associated with negative mPFC-amygdala coupling and that reexperiencing is associated with altered insula-hippocampus function, patterns of connectivity that may represent separable indicators of dysfunctional inhibitory control during affective processing.