ABCA7 Genotype Moderates the Effect of Aerobic Exercise Intervention on Generalization of Prior Learning in Healthy Older African Americans.
ABCA7 Genotype Moderates the Effect of Aerobic Exercise Intervention on Generalization of Prior Learning in Healthy Older African Americans.
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DOI：
10.3233/jad-190723
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发表时间：
2020-02
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影响因子：
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通讯作者：
Neha Sinha;Chelsie N. Berg;Ashlee Shaw;M. Gluck
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作者：
Neha Sinha;Chelsie N. Berg;Ashlee Shaw;M. Gluck
非裔美国人患与年龄相关的认知能力下降的风险较高，其阿尔茨海默病（AD）的患病率是白种人的两倍。各种行为、生物和生活方式因素可能导致这种健康差异，但对这些不同风险因素在非裔美国人中的相对重要性和相互作用知之甚少。虽然有氧运动对生物标志物的神经保护作用已经得到了很好的证实，但很少有研究根据阿尔茨海默病的遗传风险来检验运动的不同益处。此外，关于ABCA7的潜在调节作用的证据有限，该基因已知在非裔美国人中具有显著更高的阿尔茨海默病风险。在56名健康老年非洲裔美国人的病例对照匹配样本中，我们研究了有氧运动干预对ABCA7 rs3764650非风险（TT）或高风险（GG）基因型携带者的规则学习后海马相关泛化评估的影响。运动干预后，非危险组的泛化误差明显减少，而高危组的泛化误差没有改善。对于对照组，无论基因型状态如何，概化评分都没有变化。我们的研究结果表明，ABCA7高危基因型的持续不良影响可能会减少有氧运动带来的益处。因此，有氧运动对ad相关神经病理的潜在疾病改善作用可能仅限于ABCA7 rs3764650非风险基因型携带者。
African Americans are at elevated risk for age-related cognitive decline, with double the prevalence of Alzheimer's disease (AD) compared to Caucasians Americans. Various behavioral, biological, and lifestyle factors may underlie this health disparity, but little is known about the relative importance and interactions among these different risk factors in African Americans. While the neuroprotective effects of aerobic exercise on biomarkers are well established, few studies have examined the differential benefits of exercise based on genetic risk for AD. Furthermore, evidence is limited regarding the potential moderating effects of ABCA7, a gene known to confer significantly greater AD risk in African Americans. In a case-control matched sample of 56 healthy older African Americans, we investigated the effect of an aerobic exercise intervention on a hippocampus-related assessment of generalization following rule learning, in individuals who were carriers of the ABCA7 rs3764650 non-risk (TT) or high-risk (GG) genotypes. Following the exercise-intervention, the non-risk group made significantly fewer generalization errors, while there was no improvement in generalization for the high-risk group. For the controls, no changes in generalization scores were observed regardless of genotype status. Our results indicate that the ongoing adverse effects of ABCA7 high-risk genotype may diminish the benefits associated with aerobic exercise. As such, the potential disease-modifying effects of aerobic exercise on AD-related neuropathology may be limited to carriers of the ABCA7 rs3764650 non-risk genotype.