HLA antigens in juvenile arthritis
HLA antigens in juvenile arthritis
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幼年关节炎中的 HLA 抗原
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
E. Thorsby
中科院分区：
文献类型：
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作者：
Ø. Førre;J. Dobloug;H. Hoyeraal;E. Thorsby
对77例幼年型关节炎（JA）患者进行了血清学HLA分型。DR 4抗原的频率在血清反应阳性的患者中显著增加，但在血清反应阴性的患者中则下降--分别为53%和17%（P <0.025）--而在健康的挪威人中为27%。多关节型JA患者HLA-DR 4抗原阳性率为50%，明显高于多关节型JA患者的27%（P <0.05）。HLA-B27（21%）和DR 5抗原（21%）在整个患者组中的频率与对照组（分别为10%和9%，P <0.01）相比均增加。DR 5抗原在系统性发作患者中也升高（40%，P <0.05）。在少关节发病组，DR 5和DR 8抗原均升高（P分别小于0.05和0.01）。结果支持血清阳性和血清阴性JA是不同的疾病实体，血清阳性JA可能是血清阳性类风湿性关节炎的早期形式。DR 4抗原与IgM类风湿因子之间的关联表明HLA-DR 4基因或紧密连锁的基因可能调节对自身IgG的自身免疫应答。
Serologic HLA typing was performed in 77 patients with juvenile arthritis (JA). The frequency of the DR4 antigen was significantly increased in the seropositive but decreased in the seronegative patients--53% and 17%, respectively (P less than 0.025)--compared with 27% in healthy Norwegians. An increased frequency of the HLA-DR4 antigens was also found in polyarticular onset JA (50% compared with 27%, P less than 0.05). The frequency of both the HLA-B27 (21%) and the DR5 antigen (21%) was increased in the whole patient group compared with controls (10% and 9%, respectively, P less than 0.01). The DR5 antigen was also increased in the systemic onset patients (40%, P less than 0.05). Both the DR5 and the DR8 antigens were increased in the pauciarticular onset group (P less than 0.05 and P less than 0.01, respectively). The results support the view that seropositive and seronegative JA are different disease entities and also that seropositive JA may be an early form of seropositive rheumatoid arthritis. The association between the DR4 antigen and IgM rheumatoid factor suggests that the HLA-DR4 gene or a closely linked gene may regulate autoimmune responses to self IgG.