Phylogeography and Evolutionary History of Reassortant H9N2 Viruses with Potential Human Health Implications
Phylogeography and Evolutionary History of Reassortant H9N2 Viruses with Potential Human Health Implications
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DOI：
10.1128/jvi.00219-11
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发表时间：
2011-08-01
影响因子：
5.4
通讯作者：
Cattoli, Giovanni
中科院分区：
文献类型：
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作者：
Fusaro, Alice;Monne, Isabella;Cattoli, Giovanni
自1990年代中期以来，H9N2亚型禽流感病毒严重影响了远东和中东的家禽业，被认为是最有可能在人类中引起新的流感大流行的候选病毒之一。为了了解这些病毒的起源和流行病学，我们调查了1998年至2010年在9个中东和中亚国家传播的H9N2病毒全基因组序列的空间和进化动态。我们确定了四个不同的和共循环的组（A，B，C和D），其中每一个都经历了广泛的亚型间和亚型内的重组，导致产生具有未知生物学特性的病毒。我们的分析还表明，东亚是中东和中亚H9N2基因片段的主要来源，在这个地理区域，国内进化在形成病毒遗传多样性方面发挥了比国家间迁移更重要的作用。在H9N2病毒中发现的遗传变异与特定的氨基酸取代有关，据信这些氨基酸取代会导致哺乳动物中的传播性增加，以及对抗病毒药物的耐药性。我们的研究强调，需要不断监测H9N2病毒在家禽中的演变，以更好地了解这些病毒对人类健康构成的潜在风险。
Avian influenza viruses of the H9N2 subtype have seriously affected the poultry industry of the Far and Middle East since the mid-1990s and are considered one of the most likely candidates to cause a new influenza pandemic in humans. To understand the genesis and epidemiology of these viruses, we investigated the spatial and evolutionary dynamics of complete genome sequences of H9N2 viruses circulating in nine Middle Eastern and Central Asian countries from 1998 to 2010. We identified four distinct and cocirculating groups (A, B, C, and D), each of which has undergone widespread inter- and intrasubtype reassortments, leading to the generation of viruses with unknown biological properties. Our analysis also suggested that eastern Asia served as the major source for H9N2 gene segments in the Middle East and Central Asia and that in this geographic region within-country evolution played a more important role in shaping viral genetic diversity than migration between countries. The genetic variability identified among the H9N2 viruses was associated with specific amino acid substitutions that are believed to result in increased transmissibility in mammals, as well as resistance to antiviral drugs. Our study highlights the need to constantly monitor the evolution of H9N2 viruses in poultry to better understand the potential risk to human health posed by these viruses.