Allopurinol is the most common cause of Stevens-Johnson syndrome and toxic epidermal necrolysis in Europe and Israel
Allopurinol is the most common cause of Stevens-Johnson syndrome and toxic epidermal necrolysis in Europe and Israel
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DOI：
10.1016/j.jaad.2007.08.036
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发表时间：
2008-01-01
影响因子：
13.8
通讯作者：
Roujeau, Jean-Claude
中科院分区：
文献类型：
--
作者：
Halevy, Sitna;Ghislain, Pierre-Dominique;Roujeau, Jean-Claude
背景：Stevens-Johnson综合征（SJS）和中毒性表皮坏死松解症（TEN）是罕见的严重皮肤不良反应。目的：我们寻求更新关于SJS或TEN病因的知识，重点关注别嘌呤醇相关病例的发生率，并确定别嘌呤醇相关SJS或TEN的危险因素。方法：我们进行了一项多国病例对照研究。结果：共纳入379例经验证为SJS或TEN的严重皮肤不良反应患者和1505例匹配的住院对照患者。别嘌呤醇是与SJS或TEN最常相关的药物，有66例暴露患者（17.4%）和28例暴露对照组（1.9%）（校正优势比= 18,95%可信区间：11-32）。别嘌呤醇的使用比之前的欧洲病例对照研究要多。每日收盘价等于或大于200mg与较低收盘价（校正比值比= 3.0,95%置信区间：1.1-8.4）相比，风险更高（校正比值比= 36,95%置信区间：17-76）。风险仅限于短期使用(
Background: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare severe Cutaneous adverse reactions.Objectives: We Sought to Update knowledge on the causes of SJS or TEN with a focus on the rate of allopurinol-associated cases and to identify risk factors for allopurinol-associated SJS or TEN.Methods: We conducted a multinational case-control Study.Results: In all, 379 patients with severe cutaneous adverse reactions validated as SJS or TEN and 1505 matched hospitalized control subjects were enrolled. Allopurinol was the drug most frequently associated with SJS or TEN, with 66 exposed patients (17.4%) and 28 exposed control subjects (1.9%) (adjusted odds ratio = 18, 95% confidence interval: 11-32). Allopurinol use was greater than in a previous case-control European study. Daily closes equal to or greater than 200 mg were associated with a higher risk (adjusted odds ratio = 36, 95% confidence interval: 17-76) than lower closes (adjusted odds ratio = 3.0, 95% confidence interval: 1.1-8.4). The risk was restricted to short-term use (