Association of mitral annulus calcification, aortic valve sclerosis and aortic root calcification with abnormal myocardial perfusion single photon emission tomography in subjects age ≤65 years old
Association of mitral annulus calcification, aortic valve sclerosis and aortic root calcification with abnormal myocardial perfusion single photon emission tomography in subjects age ≤65 years old
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DOI：
10.1016/s0735-1097(01)01678-3
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发表时间：
2001-12-01
影响因子：
24
通讯作者：
Siegel, RJ
中科院分区：
文献类型：
--
作者：
Jeon, DS;Atar, S;Siegel, RJ
我们检验了二尖瓣环钙化（MAC）、主动脉瓣硬化（AVS）和主动脉根部钙化（ARC）与年龄小于或等于65岁的受试者的冠状动脉疾病（CAD）相关的假设。老年人中AVS和ARC常同时存在，并与冠心病危险因素和CAD相关。等于65岁，接受了心肌灌注单光子发射计算机断层扫描（SPECT）和二维经胸超声心动图对胸痛的其他适应症评价。结果与无钙沉积或有钙沉积、无冠心病危险因素或有冠心病危险因素（除糖尿病外）相比，多（大于或等于2）钙（或硬化）糖尿病或多发性硬化症（大于或等于2）冠状动脉危险因素与年龄小于或等于55岁的女性SPECT异常显著相关（比值比[OR]，20.00），女性年龄>55岁（OR，10.00）和男性年龄小于或等于55岁（OR，5.55）。多变量分析确定多个钙沉积是女性SPECT异常的重要预测因素（p < 0.001），年龄<55岁的年轻受试者（p < 0.05），总受试者组（p < 0.01）。结论当还考虑冠状动脉危险因素时，二尖瓣环中存在多个钙沉积，主动脉瓣或主动脉根似乎是小于或等于55岁的男性和女性中CAD的标志物。（J Am科尔心脏病学杂志2001;38：1988-93）（C）美国心脏病学会2001年。
OBJECTIVES We examined the hypothesis that mitral annulus calcification (MAC), aortic valve sclerosis (AVS) and aortic root calcification (ARC) are associated with coronary artery disease (CAD) in subjects age less than or equal to 65 years.BACKGROUND Mitral annulus calcification, AVS and ARC frequently coexist and arc associated with coronary risk factors and CAD in the elderly.METHODS We studied 338 subjects age less than or equal to 65 years who underwent evaluation of chest pain with myocardial perfusion single photon emission computed tomography (SPECT) and a two-dimensional transthoracic echocardiogram for other indications. The association of MAC, AVS and ARC with abnormal SPECT was evaluated by using chi-square analyses and logistic regression analyses.RESULTS Compared with no or one calcium deposit and no or one coronary risk factor other than diabetes, multiple (greater than or equal to2) calcium (or sclerosis) deposits with diabetes or multiple (greater than or equal to2) coronary risk factors were significantly associated with abnormal SPECT in women age less than or equal to 55 years old (odds ratio [OR], 20.00), in women age >55 years old (OR, 10,00) and in men age less than or equal to 55 years old (OR, 5.55). Multivariate analyses identified multiple calcium deposits as a significant predictor for an abnormal SPECT in women (p < 0.001), younger subjects age 55 years (p < 0.05) and the total group of subjects (p < 0.01).CONCLUSIONS When coronary risk factors are also taken into consideration, the presence of multiple calcium deposits in the mitral annulus, aortic valve or aortic root appears to be a marker of CAD in men less than or equal to 55 years old and women. (J Am Coll Cardiol 2001;38:1988-93) (C) 2001 by the American College of Cardiology.