Multitheragnostic Multi-GNRs Crystal-Seeded Magnetic Nanoseaurchin for Enhanced In Vivo Mesenchymal-Stem-Cell Homing, Multimodal Imaging, and Stroke Therapy
Multitheragnostic Multi-GNRs Crystal-Seeded Magnetic Nanoseaurchin for Enhanced In Vivo Mesenchymal-Stem-Cell Homing, Multimodal Imaging, and Stroke Therapy
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DOI：
10.1002/adma.201502784
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发表时间：
2015-11-04
影响因子：
29.4
通讯作者：
Shyu, Woei-Cherng
中科院分区：
文献类型：
--
作者：
Chen, Po-Jung;Kang, Yi-Da;Shyu, Woei-Cherng
利用脐带间充质干细胞的内吞作用，制备了一种嵌入氧化铁纳米颗粒的介孔二氧化硅纳米球和多金纳米棒晶体种子的多功能纳米探针。该纳米平台能够实现高效的磁遥控引导干细胞归巢，并提供光声成像和磁共振成像的双重模式，用于原位跟踪和长期监测，以达到治疗效果。
A multifunctional nanoseaurchin probe in which mesoporous silica nanobeads with iron oxide nanoparticles embedded and multi-gold nanorods crystal-seeded are fabricated and labeled with umbilical cord mesenchymal stem cells through endocytosis. This nanoplatform enables efficient magnetic remote-controlled guiding for stem cell homing, and provides dual modalities of photoacoustic imaging and magnetic resonance imaging for in situ tracking and long-term monitoring to achieve therapeutic efficacy.