Macrophage Plasticity and Polarization in Liver Homeostasis and Pathology
Macrophage Plasticity and Polarization in Liver Homeostasis and Pathology
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DOI：
10.1002/hep.26754
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发表时间：
2014-05-01
期刊：
影响因子：
13.5
通讯作者：
Mantovani, Alberto
中科院分区：
文献类型：
--
作者：
Sica, Antonio;Invernizzi, Pietro;Mantovani, Alberto
驻留和募集的巨噬细胞是肝脏稳态功能及其对组织损伤的反应的关键参与者。响应于环境信号，巨噬细胞经历极化活化至M1或M2或M2样活化状态。这些都是激活态宇宙中光谱的极端。单核吞噬细胞极化激活的分子机制研究取得了进展。驻留和募集的巨噬细胞是肝组织多种稳态和病理反应的关键组成部分。极化巨噬细胞与肝祖细胞相互作用，整合代谢适应，介导对感染因子的反应，与肝星状细胞阴阳相互作用中协调纤维化，并且是肿瘤促进炎症的关键组分。结论：更好地了解肝脏稳态和病理中巨噬细胞的多样性和可塑性可能为创新的诊断和治疗方法铺平道路。（肝病学2014;59：2034-2042）
Resident and recruited macrophages are key players in the homeostatic function of the liver and in its response to tissue damage. In response to environmental signals, macrophages undergo polarized activation to M1 or M2 or M2-like activation states. These are extremes of a spectrum in a universe of activation states. Progress has been made in understanding the molecular mechanisms underlying the polarized activation of mononuclear phagocytes. Resident and recruited macrophages are a key component of diverse homeostatic and pathological responses of hepatic tissue. Polarized macrophages interact with hepatic progenitor cells, integrate metabolic adaptation, mediate responses to infectious agents, orchestrate fibrosis in a yin-yang interaction with hepatic stellate cells, and are a key component of tumor-promoting inflammation. Conclusion: A better understanding of macrophage diversity and plasticity in liver homeostasis and pathology may pave the way to innovative diagnostic and therapeutic approaches. (Hepatology 2014;59:2034-2042)