Fiber-based hand-held RCM-OCT probe for noninvasive assessment of skin lesions and therapy guidance.
Fiber-based hand-held RCM-OCT probe for noninvasive assessment of skin lesions and therapy guidance.
复制标题
基于光纤的手持式 RCM-OCT 探头，用于无创评估皮肤病变和治疗指导。
DOI：
10.1002/tbio.202200002
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发表时间：
2022
影响因子：
--
通讯作者：
Iftimia,Nicusor
中科院分区：
文献类型：
--
作者：
Maguluri,Gopi;Grimble,John;Mujat,Mircea;Park,Jesung;Caron,Aliana;Iftimia,Nicusor
Noninvasive assessment of skin lesions, especially of basal cell carcinoma (BCC), has benefited more recently from the use of optical imaging techniques such as optical coherence tomography (OCT) and reflectance confocal microscopy (RCM). While RCM provides submicron scale resolution and thus enables identification of skin morphological changes of the skin, with the downside of limited penetration depth, OCT imaging of the same lesion brings the benefit of better resolving its depth of invasion. OCT and RCM can be used either individually or combined within the same instrument for the noninvasive diagnosis of nonmelanoma skin cancers (NMSCs). Their combined use has shown to provide certain benefits such as better characterization of the lesion's margins, both in depth and laterally, as well as improved sensitivity and specificity, as previously demonstrated by our team. In this article we report a new “fiber‐based” implementation of the second‐generation RCM‐OCT hand‐held probe. The fiber‐based implementation of both imaging modalities enabled the construction of a smaller footprint/lower weight hand‐held probe. Its preliminary evaluation on the skin of healthy volunteers is reported here, demonstrating improved capabilities for resolving sub‐cellular structures and image skin morphology with micron‐scale resolution to a higher depth than in the previous implementation, while also enabling the construction of angiography maps showing vascular remodeling.
