The Drosophila melanogaster cinnabar gene is a cell autonomous genetic marker in Aedes aegypti (Diptera: Culicidae).
The Drosophila melanogaster cinnabar gene is a cell autonomous genetic marker in Aedes aegypti (Diptera: Culicidae).
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果蝇朱砂基因是埃及伊蚊（双翅目：蚊科）的细胞自主遗传标记。
DOI：
10.1093/jmedent/42.4.716
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发表时间：
2005
影响因子：
2.1
通讯作者：
O'Brochta,DavidA
中科院分区：
文献类型：
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作者：
Sethuraman,Nagaraja;O'Brochta,DavidA
Thecinnabargene ofDrosophila melanogaster(Meigen) encodes forkynurenine hydroxylase, an enzyme involved in ommochrome biosynthesis. This gene is commonly included as a visible genetic marker in gene vectors used to create transgenicAedes aegypti(L.) that are homozygous for thekhwallele, the mosquito homolog ofcinnabar. Unexpectedly, the phenotype of cells expressingkynurenine hydroxylasein transgenicAe.aegyptiis cell autonomous as demonstrated by the recovery of insects heterozygous for thekynurenine hydroxylasetransgene with mosaic eye color patterns. In addition, a transgenic gynandromorph was recovered in which one-half of the insect was expressing thekynurenine hydroxylasetransgene, including one eye with red pigmentation, whereas the other half of the insect was homozygouskhwand included a white eye. The cell autonomous behavior ofcinnabarin transgenicAe.aegyptiis unexpected and increases the utility of this genetic marker.
