Vertebrobasilar dolichoectasia as a risk factor for cerebral microbleeds
Vertebrobasilar dolichoectasia as a risk factor for cerebral microbleeds
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DOI：
10.1111/ene.12075
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发表时间：
2013-05-01
影响因子：
5.1
通讯作者：
Bae, H. -J.
中科院分区：
文献类型：
--
作者：
Park, J. -M.;Koo, J. -S.;Bae, H. -J.
背景 椎基底动脉延长扩张症（VBD）和脑微出血（CMB）均与脑出血的风险相关。我们的目的是研究缺血性中风患者中 VBD 和 CMB 之间的关系。方法 从前瞻性卒中登记处回顾性招募连续 182 名因缺血性卒中或短暂性脑缺血发作 (TIA) 住院并接受梯度回波脑磁共振成像的患者。 CMB 位置分为前循环和后循环。扩张被定义为基底动脉（BA）直径> 4.5毫米，而多长症被定义为鞍上池上方或斜坡或鞍背边缘外侧的BA分叉。使用二元和多项 Logistic 回归模型分析 VBD 是否与大脑中任何位置或前循环或后循环区域的 CMB 相关。结果 24 名受试者 (13.2%) 患有 VBD，48 名受试者 (26.4%) 患有 CMB。与没有 VBD 的患者相比，在 VBD 患者中更频繁地观察到 CMB（66.7% vs. 20.3%，P
Background Both vertebrobasilar dolichoectasia (VBD) and cerebral microbleeds (CMBs) are related with the risk of intracerebral hemorrhage. We aimed to examine the relationship between the VBD and CMB in ischaemic stroke patients. Methods A consecutive series of 182 patients hospitalized because of ischaemic stroke or transient ischaemic attack (TIA), and who underwent gradient echo brain magnetic resonance imaging were retrospectively recruited from a prospective stroke registry. CMB locations were categorized into anterior and posterior circulation. Ectasia was defined as basilar artery (BA) diameter >4.5mm, and dolichosis, as either BA bifurcation above the suprasellar cistern or lateral to the margin of the clivus or dorsum sellae. Whether VBD is associated with CMB anywhere in the brain or in anterior or posterior circulation territories was analysed using binary and multinomial logistic regression models. Results Twenty-four subjects (13.2%) had VBD and 48 (26.4%) had CMBs. CMBs were more frequently observed in patients with VBD than without (66.7% vs. 20.3%, P