Variations in muscle tone of the human rectum: recordings with an electromechanical barostat.
Variations in muscle tone of the human rectum: recordings with an electromechanical barostat.
复制标题
DOI：
10.1152/ajpgi.1991.260.1.g17
复制
发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Andrew M. Bell;J. H. Pemberton;R. B. Hanson;A. Zinsmeister
中科院分区：
文献类型：
--
作者：
Andrew M. Bell;J. H. Pemberton;R. B. Hanson;A. Zinsmeister
直肠壁张力（直肠肌层的收缩状态）应调节调节并影响直肠排空。然而，这种音调的变化只能从用传统测压法记录的基线压力的变化来推断。我们使用等压容量装置（直肠机电恒压器）来量化直肠壁的张力变化，以响应进食和响应药物新斯的明和胰高血糖素的扰动。恒压器通过测量其倒数来间接定量肌肉壁张力，例如，通过电子反馈机制保持在恒定且预先选择的压力的松弛腔内袋内的空气体积。将恒压器以及三通道灌注测压导管放置在 14 名健康志愿者的直肠中。观察到三种变化模式：1) 呼吸波动，2) 快速容量波，3) 缓慢容量变化。禁食期间直肠张力变化不大；袋内体积的快速或缓慢变化并不常见。摄入标准餐后，恒压袋体积显着减少（空腹 85 +/- 6 ml 对比进食 50 +/- 8 ml，P 小于 0.05）。药物也会引起可预测的反应；新斯的明减少了袋体积并诱导了阶段性压力活动，而胰高血糖素消除了阶段性压力活动并增加了恒压袋体积。灌注测压导管显示基线压力没有伴随变化。我们得出的结论是，直肠恒压器测量了人类直肠张力的变化，而传统测压技术无法记录这些变化。直肠张力的这些变化可能具有重要的功能意义。
Rectal wall tone (the contractile state of the rectal tunica muscularis) should mediate accommodation and influence rectal emptying. Such changes in tone however can be only inferred from changes in baseline pressure recorded with conventional manometry. We used an isobaric volumetric device, the rectal electromechanical barostat, to quantify variations in tone of the rectal wall in response to feeding and to perturbations in response to the pharmacological agents neostigmine and glucagon. The barostat quantitates muscular wall tone indirectly by measuring its reciprocal, e.g., the volume of air within a flaccid intraluminal bag that is maintained at a constant and preselected pressure, by an electronic feedback mechanism. The barostat as well as a three-channel perfused manometric catheter were positioned in the rectum of 14 healthy volunteers. Three patterns of changes were observed: 1) respiratory fluctuations, 2) rapid volume waves, and 3) slow volume changes. Rectal tone varied little during fasting; rapid or slow changes in intrabag volume were infrequent. Ingestion of a standard meal was followed by a significant decrease in barostat bag volume (85 +/- 6 ml fasting vs. 50 +/- 8 ml fed, P less than 0.05). Pharmacological agents also induced predictable responses; neostigmine decreased bag volume and induced phasic pressure activity, whereas glucagon abolished phasic pressure activity and increased barostat bag volume. Perfused manometric catheters showed no concomitant changes in baseline pressure. We concluded that a rectal barostat measured variations in human rectal tone, which were not recorded by conventional manometric techniques. These changes in rectal tone might have important functional significance.