Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS
Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS
复制标题
DOI：
10.1038/nm0297-212
复制
发表时间：
1997-02-01
期刊：
影响因子：
82.9
通讯作者：
RowlandJones, S
中科院分区：
文献类型：
--
作者：
Goulder, PJR;Phillips, RE;RowlandJones, S
HIV特异性细胞毒性T淋巴细胞（CTL）在HIV感染中的确切作用仍存在争议。尽管在无症状阶段产生了强烈的CTL应答，但病毒仍然存在，最终发展为AIDS。有人认为，病毒是如此多变，病毒周转如此之大，逃避CTL识别将不断发生，但到目前为止，有CTL逃逸的证据有限。相反的论点是，CTL逃逸的证据是存在的，但很难找到，因为多种抗HIV免疫应答在感染的无症状阶段同时起作用。我们描述了六个捐助者谁作出强烈的CTL反应的免疫显性HLA-B27限制性表位。在进展为AIDS的两个供体中，观察到CTL通过相同突变逃逸至固定，但仅在表位稳定9-12年后。CTL逃逸可能在HIV感染的发病机制中起重要作用。
The precise role played by HIV-specific cytotoxic T lymphocytes (CTL) in HIV infection remains controversial. Despite strong CTL responses being generated during the asymptomatic phase, the virus persists and AIDS ultimately develops. It has been argued that the virus is so variable, and the virus turnover so great that escape from CTL recognition would occur continually, but so far there is limited evidence for CTL escape. The opposing argument is that evidence for CTL escape is present but hard to find because multiple anti-HIV immune responses are acting simultaneously during the asymptomatic phase of infection. We describe six donors who make a strong CTL response to an immunodominant HLA-B27-restricted epitope. In the two donors who progressed to AIDS, CTL escape to fixation by the same mutation was observed, but only after 9-12 years of epitope stability. CTL escape may play an important role in the pathogenesis of HIV infection.