(2S,3R)-2-aminododecan-3-ol, a new antifungal agent from the ascidian Clavelina oblonga
(2S,3R)-2-aminododecan-3-ol, a new antifungal agent from the ascidian Clavelina oblonga
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DOI：
10.1021/np049782q
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发表时间：
2004-11-01
影响因子：
5.1
通讯作者：
Berlinck, RGS
中科院分区：
文献类型：
--
作者：
Kossuga, MH;MacMillan, JB;Berlinck, RGS
从巴西采集的海鞘 Clavelina oblonga 中分离出一种新的抗真菌剂 (2S,3R)-2-aminododecan-3-ol (1)。通过分析光谱数据确定了 1 的结构，包括通过二苯甲酰衍生物 2 的圆二色性分析确定的绝对立体化学。化合物 1 对白色念珠菌 ATCC 10231 具有抗真菌活性，MIC 为 0.7 mug/mL，对光滑念珠菌具有 MIC 为 30 mug/mL。
A new antifungal agent, (2S,3R)-2-aminododecan-3-ol (1), has been isolated from the ascidian Clavelina oblonga collected in Brazil. The structure of 1 was established by analysis of spectroscopic data, including absolute stereochemistry determined by circular dichroism analysis of the dibenzoyl derivative 2. Compound 1 displayed antifungal activity against Candida albicans ATCC 10231 with a MIC of 0.7 mug/ mL and against Candida glabrata with a MIC of 30 mug/mL.