Cinacalcet for Hypercalcemia Caused by Pulmonary Squamous Cell Carcinoma Producing Parathyroid Hormone-Related Peptide
Cinacalcet for Hypercalcemia Caused by Pulmonary Squamous Cell Carcinoma Producing Parathyroid Hormone-Related Peptide
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DOI：
10.1159/000335676
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发表时间：
2012-01-01
影响因子：
0.8
通讯作者：
de Boer, Hans
中科院分区：
文献类型：
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作者：
Bech, Anneke;Smolders, Koen;de Boer, Hans
背景资料：目前对产生甲状旁腺素相关肽（PTH-rp）的肺细胞癌引起的高钙血症的治疗效果有限，可能是因为它们对PTH-rp分泌缺乏影响。在这种情况下，我们探讨了疗效的拟钙西那卡塞作为抑制剂的PTH-RP production.Patient：一个57岁的男性与严重和复发性高钙血症引起的PTH-RP生产鳞状细胞肺癌，阶段cT 4 N3 M1 b，不良反应的标准treatment.Results：血清PTH-RP水平不受生理盐水，降钙素或唑来膦酸盐。化疗和西那卡塞单药治疗期间PTH-rp降低。化疗加西那卡塞的组合是最有效的快速降低血清钙和PTHrp.Conclusion：这种情况下的研究是第一次表明，西那卡塞可能是在某些情况下的PTH-rp依赖性高钙血症的价值。需要确凿的证据。
Background: Current treatments for hypercalcemia caused by lung cell carcinomas producing parathyroid hormone-related peptide (PTH-rp) have limited efficacy, probably because of their lack of effect on PTH-rp secretion. In this case study we explored the efficacy of the calcimimetic cinacalcet as suppressor of PTH-rp production.Patient: A 57-year-old male with severe and recurrent hypercalcemia induced by a PTH-rpproducing squamous cell lung carcinoma, stage cT4N3M1b, poorly responding to standard treatments.Results: Serum PTH-rp levels were not affected by saline, calcitonin or zoledronate. PTH-rp decreased during chemotherapy and cinacalcet monotherapy. The combination of chemotherapy plus cinacalcet was most effective in rapidly reducing serum calcium and PTHrp.Conclusion: This case study is the first to suggest that cinacalcet may be of value in some cases of PTH-rp-dependent hypercalcemia. Corroborative evidence is needed.