The history and promising future of phage therapy in the military service
The history and promising future of phage therapy in the military service
复制标题
DOI：
10.1097/ta.0000000000001809
复制
发表时间：
2018-07-01
影响因子：
3.4
通讯作者：
Hazan, Ronen
中科院分区：
文献类型：
--
作者：
Gelman, Daniel;Eisenkraft, Arik;Hazan, Ronen
细菌对大多数（如果不是全部）可用抗生素的耐药性不断发展是一个世界性问题。这些菌株经常从军事相关环境中分离出来，因此迫切需要开发补充抗感染方式。主要方向之一是噬菌体疗法，其中包括使用噬菌体（专门针对细菌的病毒）作为生物疗法。尽管噬菌体直到最近几年才在西方被忽视，但一个多世纪以来，噬菌体在前苏联和东欧已得到广泛研究和临床应用，人们发现噬菌体在对抗多种传染病方面具有令人难以置信的效率。在这篇综述中，我们讨论了噬菌体疗法作为军事医学相关耐药细菌传染病解决方案的巨大潜力。通过描述噬菌体疗法的历史发展和获得的知识，我们定义了噬菌体在多种环境下对抗耐药细菌的优势，例如创伤损伤和食源性疾病，作为生物战制剂的预防工具和治疗方法等。我们还展示了噬菌体在全球军事环境中最新成功的临床应用。我们相信，通过整合噬菌体疗法来增强军事医学是为迅速到来的后抗生素时代做好准备的重要且必要的一步。 （版权所有 (C) 2018 Wolters Kluwer Health, Inc. 保留所有权利。）
The continuous evolvement of bacterial resistance to most, if not all, available antibiotics is a worldwide problem. These strains, frequently isolated from military-associated environments, have created an urgent need to develop supplementary anti-infective modalities. One of the leading directions is phage therapy, which includes the administration of bacteriophages, viruses that specifically target bacteria, as biotherapies. Although neglected in the West until recent years, bacteriophages have been widely studied and clinically administered in the former Soviet Union and Eastern Europe for over a century, where they were found to be incredibly efficient at battling numerous infectious diseases. In this review, we discuss the high potential of phage therapy as a solution for resistant bacterial infectious diseases relating to military medicine. By describing the historical development and knowledge acquired on phage therapy, we define the advantages of bacteriophages for combating resistant bacteria in multiple settings, such as trauma injuries and foodborne illnesses, as a preventive tool and therapy against biological warfare agents, and more. We also present the most recent successful clinical applications of bacteriophages in military settings worldwide. We believe that augmenting military medicine by integrating phage therapy is an important and required step in preparedness for the rapidly approaching post-antibiotic era. (Copyright (C) 2018 Wolters Kluwer Health, Inc. All rights reserved.)