Racial/ethnic disparities in environmental endocrine disrupting chemicals and women's reproductive health outcomes: epidemiological examples across the life course.
Racial/ethnic disparities in environmental endocrine disrupting chemicals and women's reproductive health outcomes: epidemiological examples across the life course.
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DOI：
10.1007/s40471-016-0073-9
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发表时间：
2016-06
影响因子：
3.3
通讯作者：
Zota AR
中科院分区：
文献类型：
--
作者：
James-Todd TM;Chiu YH;Zota AR
妇女在整个生命过程中生殖健康结果的差异已得到充分记录。内分泌干扰化学品可能是造成差异的一个因素，因为研究表明，非白人接触某些环境内分泌干扰化学品的比例较高，如某些邻苯二甲酸酯、双酚A、对羟基苯甲酸酯和多溴二苯醚。然而，有限数量的研究集中在这些化学品暴露作为妇女生殖健康结果的种族/民族差异的潜在媒介，如青春期发育，纤维瘤，不孕症和妊娠并发症。鉴于种族/民族是一个社会结构，本次审查的目的是目前的状态，在环境内分泌干扰化学品的种族/民族差异的文献，以及这些化学品和选定的妇女的生殖健康结果之间的关联。我们的目标是评估来自美国人群的文献，以：1）描述环境内分泌干扰化学品的种族/民族差异，2）系统地回顾环境内分泌干扰化学品的文献，以及包含一个以上种族/民族群体的人群中选定的女性健康结果。本次审查强调，今后需要开展工作，以确定某些环境内分泌干扰化学品的较高暴露是否可以部分解释这些较高暴露和高风险群体中妇女生殖健康结果的差异。
Disparities in women’s reproductive health outcomes across the life course have been well-documented. Endocrine disrupting chemicals may be one factor driving disparities, as studies suggest exposure to certain environmental endocrine disrupting chemicals, such as certain phthalates, bisphenol A, parabens and polybrominated diphenyl ethers are higher in non-whites. Yet, a limited amount of research has focused on these chemical exposures as a potential mediator of racial/ethnic differences in women’s reproductive health outcomes, such as pubertal development, fibroids, infertility, and pregnancy complications. Given that race/ethnicity is a social construct, the purpose of this review was to present the current state of the literature on racial/ethnic disparities in both environmental endocrine disrupting chemicals, as well as associations between these chemicals and selected women’s reproductive health outcomes. Our goal was to evaluate literature from populations based in the United States to: 1) characterize racial/ethnic differences in environmental endocrine disrupting chemicals and 2) systematically review literature on environmental endocrine disrupting chemicals and selected women’s health outcomes in populations containing more than one racial/ethnic group. This review highlights the need for future work in determining whether higher exposures to some environmental endocrine disrupting chemicals might partly explain differences in women’s reproductive health outcomes in these higher-exposure and high-risk groups.