Microfluidic Spontaneous Emulsification for Generation of O/W Nanoemulsions-Opportunity for In-Space Manufacturing.
Microfluidic Spontaneous Emulsification for Generation of O/W Nanoemulsions-Opportunity for In-Space Manufacturing.
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用于生成 O/W 纳米乳液的微流体自发乳化——太空制造的机会。
DOI：
10.1002/adhm.202203363
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发表时间：
2023
影响因子：
10
通讯作者：
Schmidt S
中科院分区：
文献类型：
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作者：
Schmidt S
通过自发自组装，展示了微流体用于水包油(O/W)纳米乳化的应用。由于这是一个较长的过程，因此对单接触和多接触微流控反应器进行了测试，后者提供了长时间、恒定的微流控处理，以保持先进的相和界面传质。与传统系统相比，微流控设备在自发乳化方面具有强大的优势，在所需的表面活性剂与油的比例(SOR)下，液滴尺寸为62纳米，加工时间减少了90%。多接触微流体具有比单接触微流体更好的性能，同时还讨论了关键方面，如工艺稳健性。通过对三组分(油、水、表面活性剂)的三元相图分析，可以确定纳米乳液的正确混合比例和混合步骤顺序。微流控自发乳化符合为太空探索中的宇航员提供强化饮料的预期应用的目标功能。在这种观点下，一个优势是获得稳定的纳米乳剂，其浓度比应用(人体摄入量)高得多，允许最终产品的稀释系数高达100。这显著减少了处理时间，并允许处理灵活性，例如，在空间稀释或定制地球制备的纳米乳剂浓缩物有效载荷。
The use of microfluidics for oil‐in‐water (O/W) nanoemulsification via spontaneous self‐assembly is demonstrated. As this is known to be a longish process, both single‐ and multicontact microfluidic reactors are tested, the latter providing a longsome, constant microfluidic treatment to maintain advanced phase and interfacial mass transfer. Microfluidic devices provide strong advantages above conventional systems for spontaneous emulsification, with droplet sizes of 62 nm at desired surfactant‐to‐oil ratios (SOR) and a decrease of 90% in process time. Multicontact microfluidics have better performance than their single‐contact counterparts, while critical aspects, e.g., process robustness, are also discussed. Ternary phase diagram analysis of the three components (oil, water, surfactant) allow to decide for the right mixing ratio and sequence of mixing steps for the nanoemulsions. Microfluidic spontaneous emulsification meets objective functions of the intended application to provide fortified beverages to astronauts in space exploration. In that viewpoint, an advantage is to achieve stable nanoemulsions at a level of concentrations much higher as compared to application (human intake), allowing a dilution factor to the final product of up to 100. This decreases notably the process time and allows for process flexibility, e.g., to dilute or tailor Earth‐prepared nanoemulsion concentrate payloads in space.