Why Depressed Mood is Adaptive: A Numerical Proof of Principle for an Evolutionary Systems Theory of Depression.
Why Depressed Mood is Adaptive: A Numerical Proof of Principle for an Evolutionary Systems Theory of Depression.
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DOI：
10.5334/cpsy.70
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Badcock PB
中科院分区：
文献类型：
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作者：
Constant A;Hesp C;Davey CG;Friston KJ;Badcock PB
我们为抑郁症的进化系统理论（EST）提供了原理证明。该理论表明，规范性抑郁症状通过社会信号增加人际支持来对抗社会环境波动，并且这种反应取决于对社会突发事件的不确定性的编码，而神经调节抗抑郁药可以针对这种不确定性进行编码。我们模拟了在社会逆境前后在社会双臂强盗任务中做出一系列决策的智能体，这导致了抑郁症状。在社会支持和药物治疗的各种组合下模拟对社会逆境的反应。正常抑郁表型对社会支持和抗抑郁药物模拟治疗有积极反应。吸引社会支持和服用抗抑郁药物也能缓解快感缺失和社交退缩，从而改善人际关系。这些结果通过证明在逆境之后，正常的抑郁情绪通过适当的人际支持或药物治疗保留了社会包容性，从而支持了抑郁症的 EST。
We provide a proof of principle for an evolutionary systems theory (EST) of depression. This theory suggests that normative depressive symptoms counter socioenvironmental volatility by increasing interpersonal support via social signalling and that this response depends upon the encoding of uncertainty about social contingencies, which can be targeted by neuromodulatory antidepressants. We simulated agents that committed to a series of decisions in a social two-arm bandit task before and after social adversity, which precipitated depressive symptoms. Responses to social adversity were modelled under various combinations of social support and pharmacotherapy. The normative depressive phenotype responded positively to social support and simulated treatments with antidepressants. Attracting social support and administering antidepressants also alleviated anhedonia and social withdrawal, speaking to improvements in interpersonal relationships. These results support the EST of depression by demonstrating that following adversity, normative depressed mood preserved social inclusion with appropriate interpersonal support or pharmacotherapy.