Superwetting Injectable Hydrogel with Ultrastrong and Fast Tissue Adhesion for Minimally Invasive Hemostasis
Superwetting Injectable Hydrogel with Ultrastrong and Fast Tissue Adhesion for Minimally Invasive Hemostasis
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超润湿注射水凝胶具有超强和快速的组织粘附力，可实现微创止血
DOI：
10.1002/adhm.202201799
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发表时间：
2022-11
影响因子：
10
通讯作者：
Mingjie Liu
中科院分区：
文献类型：
--
作者：
Congying Wei;Weili Shi;Chuangqi Zhao;Shuai Yang;Jiajia Zheng;JinPan Zhong;Tianyi Zhao;Simin Kong;Xi Gong;Mingjie Liu
可注射水凝胶最近已成为各种临床适应症缝线的替代品。然而，现有的可注射水凝胶不适合用于微创手术中的止血，因为它们的弱界面粘附和复杂/长时间的加工。本文中，开发了由带相反电荷的多糖组成的超润湿可注射水凝胶。可注射水凝胶在表面上的自发铺展通过吸收界面水实现完全润湿并形成紧密的界面接触。超润湿能力和随后的共价交联在组织表面上执行快速和超强的湿粘附（140 kPa）。离体猪和体内大鼠模型显示，水凝胶成功地导致红细胞聚集以用于靶向止血（在小于12秒内），而不需要外部止血，并且不与外周组织发生术后粘连。这进一步证明了水凝胶可以在兔模型的腹腔镜手术中作为有效的止血剂。总的来说，强湿粘附性、抗菌性能和易操作性使这种可注射水凝胶成为止血应用的有希望的候选者，因为它可以成功地将联合收割机的临床疗效和微创手术的转型机会结合起来。
Injectable hydrogels have recently emerged as alternatives to sutures for various clinical indications. However, existing injectable hydrogels are unsuitable for hemostasis in minimally invasive surgery because of their weak interfacial adhesion and complex/prolonged processing. Herein, a superwetting injectable hydrogel composed of oppositely charged polysaccharides is developed. The spontaneous spreading of the injectable hydrogel on the surfaces achieves complete wetting and forms tight interfacial contact by absorbing the interfacial water. The superwetting ability and subsequent covalent crosslinking perform fast and ultrastrong wet adhesion (140 kPa) on the tissue surface. Ex vivo porcine and in vivo rat models show that the hydrogel successfully leads to the aggregation of erythrocytes for targeted hemostasis (in less than 12 s) without requiring external adjuncts, and no postsurgical adhesions to the peripheral tissues. This further demonstrates that hydrogel can act as an effective hemostasis agent in laparoscopic surgery in a rabbit model. Overall, the strong wet adhesion, antibacterial properties, and easy operability make this injectable hydrogel a promising candidate for hemostasis applications, as it can successfully combine clinical efficacy and transformation opportunities for minimally invasive surgery.