Night Shift Work, Genetic Risk, and Hypertension
Night Shift Work, Genetic Risk, and Hypertension
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夜班工作、遗传风险和高血压
DOI：
10.1016/j.mayocp.2022.04.007
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发表时间：
2022-11-01
影响因子：
8.9
通讯作者：
Gu, Aihua
中科院分区：
文献类型：
--
作者：
Xiao, Zhihao;Xu, Cheng;Gu, Aihua
目的：进行一项前瞻性队列研究，以调查夜班工作是否与高血压事件相关，以及这种相关性是否因高血压遗传易感性而改变，因为夜班工作与高血压之间的相关性证据不足。本研究共纳入了2006年至2010年招募并观察至2018年1月31日的232，665名英国生物银行参与者。采用协变量调整的考克斯比例风险模型评估夜班工作暴露与高血压风险之间的关系。我们构建了高血压遗传易感性的多基因风险评分（PRS），用于探讨高血压遗传易感性是否会改变夜班工作的影响。结果：夜班工人的高血压危险性高于白班工人，且随夜班工作频率的增加而增加（P趋势
Objective: To perform a prospective cohort study to investigate whether night shift work is associated with incident hypertension and whether this association is modified by genetic susceptibility to hypertension because evidence on the association between night shift work and hypertension is insufficient.Methods: A total of 232,665 participants of UK Biobank who were recruited from 2006 to 2010 and observed to January 31, 2018, were included in this study. A Cox proportional hazards model with covariate adjustment was performed to assess the association between night shift work exposure and hypertension risk. We constructed a polygenic risk score (PRS) for genetic susceptibility to hypertension, which was used to explore whether genetic susceptibility to hypertension modified the effect of night shift work. The robustness of the results was assessed by sensitivity analysis.Results: Night shift workers had a higher hypertension risk than day shift workers, which increased with increasing frequency of night shift work (P-trend