Three-Dimensional (3D) Microarchitecture Correlations with 2D Projection Image Gray-Level Variations Assessed by Trabecular Bone Score Using High-Resolution Computed Tomographic Acquisitions: Effects of Resolution and Noise
Three-Dimensional (3D) Microarchitecture Correlations with 2D Projection Image Gray-Level Variations Assessed by Trabecular Bone Score Using High-Resolution Computed Tomographic Acquisitions: Effects of Resolution and Noise
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DOI：
10.1016/j.jocd.2012.05.001
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发表时间：
2013-07-01
影响因子：
2.5
通讯作者：
Hans, Didier
中科院分区：
文献类型：
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作者：
Winzenrieth, Renaud;Michelet, Franck;Hans, Didier
本研究的目的是确定使用微计算机断层扫描 (mu CT) 重建评估的骨小梁微结构的 3 维 (3D) 特征与使用直接从 3D mu CT 重建 (TBS mu CT) 得出的 2D 投影图像评估的骨小梁评分 (TBS) 之间的相关性水平。此外，我们还评估了图像退化（分辨率和噪声）和投影的 X 射线能量对这些相关性的影响。在显微扫描仪上以 93 μm 的各向同性分辨率采集了 30 块人类尸体椎骨。 3D 微架构参数使用 MicroView（GE Healthcare，Wauwatosa，MI）获得。这些 3D 模型的 2D 投影是使用不同 X 射线能量下的比尔-朗伯定律生成的。模拟了图像分辨率的下降（从 93 到 1488 μm）。使用线性回归分析评估不同分辨率下3D微结构参数和TBS mu CT之间的关系。无论分辨率如何，TBS mu CT和3D微结构参数之间都观察到显着相关性。检测到的相关性对于连接密度具有强到中等的正相关性（0.711
The aim of the present study is to determine the level of correlation between the 3-dimensional (3D) characteristics of trabecular bone microarchitecture, as evaluated using microcomputed tomography (mu CT) reconstruction, and trabecular bone score (TBS), as evaluated using 2D projection images directly derived from 3D mu CT reconstruction (TBS mu CT). Moreover, we have evaluated the effects of image degradation (resolution and noise) and X-ray energy of projection on these correlations.Thirty human cadaveric vertebrae were acquired on a microscanner at an isotropic resolution of 93 mu m. The 3D microarchitecture parameters were obtained using MicroView (GE Healthcare, Wauwatosa, MI). The 2D projections of these 3D models were generated using the Beer-Lambert law at different X-ray energies. Degradation of image resolution was simulated (from 93 to 1488 mu m). Relationships between 3D microarchitecture parameters and TBS mu CT at different resolutions were evaluated using linear regression analysis.Significant correlations were observed between TBS mu CT and 3D microarchitecture parameters, regardless of the resolution. Correlations were detected that were strongly to intermediately positive for connectivity density (0.711