Mycoplasma pneumonia of swine (MPS) resistance and immune characteristics of pig lines generated by crossing an MPS pulmonary lesion selected Landrace line and a highly immune capacity selected Large White line.
Mycoplasma pneumonia of swine (MPS) resistance and immune characteristics of pig lines generated by crossing an MPS pulmonary lesion selected Landrace line and a highly immune capacity selected Large White line.
复制标题
猪支原体肺炎(MPS)抗性和免疫特性是通过MPS肺部病变选择的长白品系和高免疫能力选择的大白品系杂交产生的猪品系。
DOI：
10.1111/asj.12529
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发表时间：
2016
影响因子：
2
通讯作者：
Suzuki K
中科院分区：
文献类型：
--
作者：
Borjigin L;Shimazu T;Katayama Y;Watanabe K;Kitazawa H;Roh SG;Aso H;Katoh K;Uchida T;Suda Y;Sakuma A;Nakajo M;Suzuki K
为了解杂交对猪肺炎支原体（MPS）抗性和免疫特性的影响，对2个杂交品系进行了鉴定。通过将MPS肺部病变选择的长白猪品系（La）和高度免疫选择的大白色品系（Wa）杂交产生一个杂交品系LaWa。第二个杂交系LaWb是由La系和未选择的大白色系（Wb）杂交产生的。以LbWb系（非选择长白系×非选择大白色系）和La系为对照。LaWa和LaWb系的MPS肺部病变水平介于La和LbWb系之间，但差异无统计学显著性。经绵羊红细胞（SRBC）刺激后，LaW B和LaWa系表现出与La系相似的免疫特性;外周血单核细胞数量增加，而B细胞、T细胞、SRBC特异性免疫球蛋白G和白细胞介素（IL）-13的分泌减少。此外，自然杀伤（NK）细胞的数量以及IL-4和IL-17的表达在LaWb和LaWa系中分别显著更高。这些数据表明，La和Wa系的杂交导致了一些选定的免疫反应的遗传。
To understand the influence of crossbreeding on Mycoplasma pneumonia of swine (MPS) resistance and immune characteristics, two crossbred lines were characterized. One crossbred line, LaWa, was generated by crossing the MPS pulmonary lesion selected Landrace line (La) and the highly immune‐selected Large White line (Wa). The second crossbred line, LaWb, was generated by crossing the La line and the nonselected Large White line (Wb). The crossbred LbWb line (nonselected Landrace line × nonselected Large White line) and the La line were used as controls. The LaWa and LaWb lines had an intermediate level of MPS lung lesions between La and LbWb lines, although the difference was not statistically significant. After stimulation with sheep red blood cells (SRBCs), the LaWb and LaWa lines showed immune characteristics similar to that of the La line; the number of monocytes in peripheral blood increased, while B cells, T cells, secretion of SRBC‐specific immunoglobulin G, and interleukin (IL)‐13 decreased. Additionally, the number of natural killer (NK) cells and the expression of IL‐4 and IL‐17 were significantly higher in the LaWb and LaWa lines, respectively. These data suggested that crossbreeding of La and Wa lines resulted in the inheritance of some of the selected immune responses.