Electroconvulsive Therapy and Schizophrenia: A Systematic Review.
Electroconvulsive Therapy and Schizophrenia: A Systematic Review.
复制标题
DOI：
10.1159/000497376
复制
发表时间：
2019-04-01
期刊：
影响因子：
--
通讯作者：
Braga, Raphael J
中科院分区：
文献类型：
--
作者：
Ali, Sana A;Mathur, Nandita;Braga, Raphael J
电休克疗法（ECT）是一种非常有效的治疗重度抑郁症，但不常用于治疗精神病性障碍。最近的文献表明，ECT可以是一个有用的策略，为广泛的精神障碍，包括难治性精神分裂症。本综述的目的是检查现存的文献ECT精神分裂症的主要重点是其疗效，其对认知功能的影响，维持ECT的作用，以及神经影像学生物标志物的潜在作用，以提供更精确的ECT治疗策略。我们评估了现有的文献，特别关注前瞻性随机试验。我们的综述表明，ECT可以是一种有效的治疗策略，在这个严重的病人群体。研究表明，虽然ECT治疗精神分裂症是一种安全的治疗方式，但必须始终仔细权衡认知障碍的可能性。新的生物标志物的使用和调查的战略，精神分裂症的药物治疗，以及这些方法的扩展到ECT进行了讨论。
Electroconvulsive therapy (ECT) is a remarkably effective treatment for major depressive disorder, but is less commonly utilized for treatment of psychotic disorders. Recent literature indicates that ECT can be a useful strategy for a wide range of psychotic disorders, including treatment-resistant schizophrenia. The purpose of this review is to examine the extant literature on ECT in schizophrenia with a primary focus on its efficacy, its impact on cognitive function, the role of maintenance ECT, and the potential role of neuroimaging biomarkers to provide more precise ECT treatment strategies. We evaluated the available literature, with a particular focus on prospective, randomized trials. Our review suggests that ECT can be an effective treatment strategy in this severely ill patient population. Studies suggest that while ECT in schizophrenia is a safe treatment modality, the potential for cognitive impairment must always be carefully weighed. The use and investigation of new biomarker strategies for the pharmacological treatment of schizophrenia, and the extension of these approaches to ECT are also discussed.