ALCOHOLISM AND MYOCARDIAL ENERGY-METABOLISM
ALCOHOLISM AND MYOCARDIAL ENERGY-METABOLISM
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DOI：
10.1111/j.1530-0277.1994.tb00892.x
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发表时间：
1994-02-01
影响因子：
3.2
通讯作者：
SPACH, PI
中科院分区：
文献类型：
--
作者：
CUNNINGHAM, CC;SPACH, PI
对动物模型中慢性乙醇消耗对心肌能量代谢影响的回顾表明，心功能的改变并不伴随着高能代谢物、ATP和磷酸肌酸水平的变化。线粒体超微结构和功能的微小改变似乎因营养摄入减少而加剧。迄今为止的观察表明，在动物模型中，慢性乙醇消耗和热量剥夺在引起心肌能量代谢改变方面存在相互作用。此外，酒精相关的超微结构改变和线粒体功能下降在肝脏中比在心脏中更明显，这强烈表明心肌比肝脏更不容易受到酒精的有害影响。
A review of the effects of chronic ethanol consumption on myocardial energy metabolism in animal models reveals that alterations in cardiac function are not accompanied by changes in the levels of the high-energy metabolites, ATP, and creatine phosphate. There are minor alterations in mitochondrial ultrastructure and function that appear to be accentuated by lowered nutrient intake. Observations to date indicate that, in animal models, there is an interaction between chronic ethanol consumption and caloric deprivation in eliciting alterations in myocardial energy metabolism. Furthermore, ethanol-related ultrastructural changes and depressed mitochondrial function are much more demonstrable in liver than in heart, suggesting strongly that the myocardium is less susceptible to the deleterious effects of alcohol than is the liver.