The strain of unfamiliar conspecifics affects stress identification in rats
The strain of unfamiliar conspecifics affects stress identification in rats
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DOI：
10.1016/j.beproc.2022.104714
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发表时间：
2022-08-05
影响因子：
1.3
通讯作者：
Takeuchi, Yukari
中科院分区：
文献类型：
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作者：
Kiyokawa, Yasushi;Kuroda, Naoko;Takeuchi, Yukari
当我们将一个人视为同一群体的成员并认识到与这个人的社会相似性时，人类会表现出不同的社会行为。一个例子是更准确地识别个人的情绪。我们之前的研究提出，老鼠能够识别出与某些不熟悉的老鼠的社会相似性。因此，不熟悉的同种菌株可能会影响大鼠的应激识别。Wistar受试大鼠被允许探索一对不熟悉的Wistar、Sprague-Dawley（SD）、Long-Evans（LE）或Fischer 344（F344）刺激大鼠。为了诱导压力的差异，其中一只刺激大鼠在测试前立即接受了足部电击。结果发现，受试者对电击Wistar和SD刺激大鼠表现出偏向性相互作用，而对电击LE和F344刺激大鼠则无偏向性相互作用。随后的实验证实，对休克的Wistar和SD刺激大鼠的偏见相互作用是由这些刺激大鼠的压力驱动的。此外，对电击LE和F344刺激大鼠缺乏偏倚相互作用似乎不是由于程序原因。使用LE受试大鼠的实验进一步证实，受到电击的LE刺激大鼠会发出求救信号。这些结果表明，Wistar大鼠可以识别不熟悉的Wistar和SD大鼠的应激，但不熟悉的LE或F344大鼠。因此，大鼠似乎认识到某些不熟悉的大鼠品系的社会相似性。
Humans show distinct social behaviours when we evaluate an individual as being a member of the same group and recognize social similarity to the individual. One example is more accurate identification of emotion in that individual. Our previous studies proposed that rats recognize social similarity to certain strains of unfamiliar rats. It is therefore possible that the strain of unfamiliar conspecifics affects stress identification in rats. Wistar subject rats were allowed to explore a pair of unfamiliar Wistar, Sprague-Dawley (SD), Long-Evans (LE), or Fischer344 (F344) stimulus rats. To induce differences in stress, one of the stimulus rats had received foot shocks imme-diately before the test. It was found that the subjects showed biased interaction towards the shocked Wistar and SD stimulus rats, but not toward the shocked LE or F344 stimulus rats. Subsequent experiments confirmed that the biased interaction towards the shocked Wistar and SD stimulus rats was driven by stress in these stimulus rats. In addition, the lack of biased interaction towards the shocked LE and F344 stimulus rats did not appear to be due to procedural reasons. The experiment using LE subject rats further confirmed that the shocked LE stimulus rats emitted distress signals. These results suggested that Wistar rats could identify stress in unfamiliar Wistar and SD rats, but not in unfamiliar LE or F344 rats. Therefore, rats appear to recognize social similarity to certain unfamiliar strains of rats.