Deep brain stimulation in the globus pallidus externa promotes sleep.
Deep brain stimulation in the globus pallidus externa promotes sleep.
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DOI：
10.1016/j.neuroscience.2016.02.032
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发表时间：
2016-05-13
期刊：
影响因子：
3.3
通讯作者：
Lu J
中科院分区：
文献类型：
--
作者：
Qiu MH;Chen MC;Wu J;Nelson D;Lu J
基底神经节是皮层下结构的网络，在运动、睡眠和精神行为中起着关键作用。基底神经节紊乱如帕金森氏病和亨廷顿氏病会影响睡眠。脑深部电刺激（DBS）治疗帕金森病的运动症状可以改善睡眠障碍。我们的一系列先前的研究导致的假设，多巴胺，作用于D2受体上的striatopallidal终端，增强活动的外部苍白球（GPe），并促进睡眠。在这里，我们测试了GPe中的DBS是否会促进大鼠的睡眠。我们发现，与假DBS刺激相比，大鼠GPe中的单侧DBS（180 Hz，100 μA）显著增加了非快速眼动和快速眼动睡眠。DBS诱发睡眠的脑电功率谱与基础睡眠相似，睡眠潜伏期不受DBS影响。GPe可能是DBS治疗基底神经节功能障碍引起的失眠和运动障碍的更好部位。
The basal ganglia, a network of subcortical structures, play a critical role in movements, sleep and mental behavior. Basal ganglia disorders such as Parkinson’s disease and Huntington’s disease affect sleep. Deep brain stimulation (DBS) to treat motor symptoms in Parkinson’s disease can ameliorate sleep disturbances. Our series of previous studies lead the hypothesis that dopamine, acting on D2 receptors on the striatopallidal terminals, enhances activity in the external globus pallidus (GPe) and promotes sleep. Here, we tested if DBS in the GPe promotes sleep in rats. We found that unilateral DBS (180 Hz at 100 μA) in the GPe in rats significantly increased both non-rapid eye movement and rapid eye movement sleep compared to sham DBS stimulation. The EEG power spectrum of sleep induced by DBS was similar to that of the baseline sleep, and sleep latency was not affected by DBS. The GPe is potentially a better site for DBS to treat both insomnia and motor disorders caused by basal ganglia dysfunction.