Characterization of the thrombogenic potential of surface oxides on stainless steel for implant purposes
Characterization of the thrombogenic potential of surface oxides on stainless steel for implant purposes
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DOI：
10.1016/s0169-4332(03)00706-2
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发表时间：
2003-12-15
影响因子：
6.7
通讯作者：
Lin, SJ
中科院分区：
文献类型：
--
作者：
Shih, CC;Shih, CM;Lin, SJ
市售支架由各种金属制成，并经过不同程度的表面氧化钝化。通过犬股骨体外回路模型探讨功能性表面氧化物对抗血栓潜力程度的影响。通过开路电位、开路电位下检测的电流密度、电化学阻抗谱、透射电子显微镜、俄歇能谱（AES）、X射线光电子能谱（XPS）和扫描电子显微镜研究了这些氧化膜的相关性能。实验证据表明，与用多晶氧化物 (PO) 钝化的钢丝或商用钢丝线圈 (AS) 钝化的钢丝相比，用无定形氧化物 (AO) 钝化的不锈钢丝在 30 分钟随访后的血凝块重量明显较低。表面表征表明，与用 PO 钝化的表面相比，用 AO 钝化的线材表面在开路电位下具有稳定的负电流密度，并且电位显着降低。 AO的时间常数比多晶氧化物的时间常数大约25倍。 PO 和 AO 之间的氧化物晶粒尺寸存在显着差异。 AES 和 XPS 光谱揭示的表面化学表明 AD 存在富铬和富氧的表面氧化物，PO 存在富铁和贫氧的表面氧化物。 AO 表面膜的这些显着特性可能为 316L 不锈钢支架提供优异的抗血栓特性。 (C) 2003 Elsevier B.V. 保留所有权利。
Marketed stents are manufactured from various metals and passivated with different degrees of surface oxidation. The functional surface oxides on the degree of antithrombotic potential were explored through a canine femoral extracorporeal circuit model. Related properties of these oxide films were studied by open-circuit potential, current density detected at open-circuit potential, the electrochemical impedance spectroscopy, transmission electron microscopy, Auger spectroscopy (AES), Xray photoelectron spectroscopy (XPS), and scanning electron microscopy. Experimental evidences showed that blood clot weight after a 30-min follow-up was significantly lower for the stainless steel wire passivated with amorphous oxide (AO) compared to the wire passivated with polycrystalline oxide (PO) or commercial as-received wire coils (AS). Surface characterizations showed that a stable negative current density at open-circuit potential and a significant lower potential were found for the wire surface passivated with AO than for the surface passivated with PO. Time constant of AO is about 25 times larger than that of polycrystalline oxide. Significant difference in oxide grain sizes was found between PO and AO. Surface chemistries revealed by the AES and XPS spectra indicated the presence of a Cr- and oxygen-rich surface oxide for AD, and a Fe-rich and oxygen-lean surface oxide for PO. These remarkable characteristics of AO surface film might have a potential to provide for excellent antithrombotic characteristics for the 316L stainless steel stents. (C) 2003 Elsevier B.V. All fights reserved.